Rockies vs. Cubs Prediction: Cubs Predicted to Win Wednesday's MLB Matchup [5/28/2025]

The Chicago Cubs will square off with the Colorado Rockies in MLB action at Wrigley Field on Wednesday, beginning at 8:05PM ET.

The Cubs will have Matthew Boyd (4-2, 3.42 ERA) as their starting pitcher, up against Tanner Gordon (1-1, 4.38 ERA) for the Rockies.

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Cubs as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Colorado-CHI Cubs game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Cubs' chance of winning at 73%, with the Rockies at 27%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Rockies vs. Cubs predictions page.

Cubs vs. Rockies Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the result of Wednesday's MLB matchup between the Rockies and Cubs 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Cubs a 73% chance of beating the Rockies.

According to our model, the Cubs (-1.5) have a 53% chance of covering the run line, while the over/under total of 7.5 runs has a 51% chance of going over.

Rockies vs. Cubs Odds [5/28/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Rockies	Cubs
Run Line	+1.5 (+124)	-1.5 (-148)
Moneyline	+295	-325
Total	o7.5 (-108)	u7.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Rockies vs. Cubs Picks and Best Bets

Our model's strongest edge in today's Rockies vs. Cubs matchup is on the over/under.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Rockies vs. Cubs Game-Day Updates and Essential Details

Wednesday's MLB matchup between the Cubs and Rockies at Wrigley Field is scheduled to begin at 8:05PM ET.

• Who: Colorado Rockies vs. Chicago Cubs
• Date: Wednesday, May 28, 2025
• Time: 8:05PM ET/5:05PM PT
• Venue: Wrigley Field

Dimers.com's comprehensive preview of Wednesday's Rockies vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Colorado vs. CHI Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
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• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Conclusion

We predict the Cubs, with a 73% win probability, will likely beat the Rockies on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Rockies vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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