College football picks today: Week 4 Saturday best bets include Wyoming vs. Colorado play [9/20/2025]

Today’s college football picks for September 20, 2025 are here, with Saturday’s college football best bets driven by tens of thousands of predictive simulations analyzing the latest odds and matchups.

These college football best bets include matchups like the Wyoming vs. Colorado game at 10:15PM ET, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge college football bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Saturday, September 20, 2025, including our full set of picks and best bets for today and the week ahead.

List of college football picks tonight [9/20, updated 10:03PM ET]

After diving deep into the numbers and conducting thousands of simulations, our famous predictive analytics model has identified the best football bets for Saturday, September 20, 2025.

Wyoming +12.5 (-112)

• Probability: 57%
• Edge: 4.2%
• Matchup: Wyoming vs. Colorado (10:15PM ET, Saturday)

Our model has pinpointed a high-probability college football betting opportunity tonight, which comes in the Wyoming vs. Colorado matchup. We recommend a spread bet on Wyoming +12.5 at -112 odds, with our analysis showing a 57% chance of hitting and a compelling edge of 4.2%.

Wyoming ML (+375)

• Probability: 24.1%
• Edge: 3.0%
• Matchup: Wyoming vs. Colorado (10:15PM ET, Saturday)

Our model has found another strong college football bet for Saturday's sports action, again in the game between Wyoming and Colorado. We suggest placing a wager on Wyoming ML at +375 odds, with a 24.1% probability delivering a 3.0% edge.

NCAAF best bets: Saturday, 9/20/2025

As of 10:03PM ET, here are our top two college football bets by probability recommended by our model:

Matchup	Bet	Odds	Probability	Edge
Wyoming vs. Colorado	Wyoming +12.5	-112 @ DraftKings	57%	4.2%
Wyoming vs. Colorado	Wyoming ML	+375 @ BetMGM	24.1%	3.0%

Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Today, Dimers Pro subscribers have access to three NCAAF picks—with access to all of these being what makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for September 20, 2025.

List of upcoming college football games to bet on now

• Wyoming vs. Colorado (10:15PM ET, Saturday)
• California vs. San Diego State (10:30PM ET, Saturday)
• Michigan State vs. Southern California (11:00PM ET, Saturday)
• Fresno State vs. Hawaii (12:00AM ET, Sunday)

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More about college football

The bets on this page form part of our college football player props and college football best bets series.

For more NCAAF betting content, we have college football betting news and the latest National Championship odds and predictions.

Conclusion

Our college football best bets are locked and loaded for September 20, 2025, featuring plays such as Wyoming +12.5 and Wyoming ML. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate college football insights quickly, with human oversight ensuring high editorial quality. Our predictions are sourced from current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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