College football picks today: Week 5 Friday best bets include TCU vs. Arizona State play [9/26/2025]

Today’s college football picks for September 26, 2025 are here, with Friday’s college football best bets driven by tens of thousands of predictive simulations analyzing the latest odds and matchups.

These college football best bets include matchups like the TCU vs. Arizona State game at 9:00PM ET, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge college football bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Friday, September 26, 2025, including our full set of picks and best bets for today and the week ahead.

List of college football picks tonight [9/26, updated 8:33PM ET]

After digging deep into the numbers and running thousands of simulations, our leading predictive analytics model has figured out the best football bets for Friday, September 26, 2025.

Arizona State ML (-142)

• Probability: 62.1%
• Edge: 3.4%
• Matchup: TCU vs. Arizona State (9:00PM ET, Friday)

Our model has pinpointed a high-probability college football betting opportunity tonight, which comes in the TCU vs. Arizona State game. We recommend a bet on the Arizona State ML at -142 odds, with our analysis showing a 62.1% chance of hitting and a compelling edge of 3.4%.

Arizona State -3 (-105)

• Probability: 55.7%
• Edge: 4.5%
• Matchup: TCU vs. Arizona State (9:00PM ET, Friday)

Our model has found another strong college football bet for Friday's sports action, again in the matchup between TCU and Arizona State. We suggest placing a spread wager on Arizona State -3 at -105 odds, with a 55.7% probability delivering a 4.5% edge.

NCAAF best bets: Friday, 9/26/2025

As of 8:33PM ET, here are our top two college football bets by probability recommended by our model:

The bets listed here are sorted by win probability—but the real path to profit lies in high-edge plays. Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Among today's NCAAF picks is a -110 spread bet with a 11.1% edge—the kind of high-upside play that makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for September 26, 2025.

List of upcoming college football games to bet on now

• TCU vs. Arizona State (9:00PM ET, Friday)
• Houston vs. Oregon State (10:30PM ET, Friday)
• Notre Dame vs. Arkansas (12:00PM ET, Saturday)
• Southern California vs. Illinois (12:00PM ET, Saturday)
• Duke vs. Syracuse (12:00PM ET, Saturday)
• Georgia Tech vs. Wake Forest (12:00PM ET, Saturday)
• Louisville vs. Pittsburgh (12:00PM ET, Saturday)
• Rutgers vs. Minnesota (12:00PM ET, Saturday)
• UCF vs. Kansas State (12:00PM ET, Saturday)
• South Alabama vs. North Texas (12:00PM ET, Saturday)

More about college football

The bets on this page form part of our college football player props and college football best bets series.

For more NCAAF betting content, we have college football betting news and the latest National Championship odds and predictions.

Conclusion

Our college football best bets are locked and loaded for September 26, 2025, featuring plays such as Arizona State ML and Arizona State -3. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate college football insights quickly, with human oversight ensuring high editorial quality. Our predictions are grounded in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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