College football picks today: Week 4 Friday best bets include Iowa vs. Rutgers play [9/19/2025]

Today’s college football picks for September 19, 2025 are here, with Friday’s college football best bets driven by thousands of predictive simulations analyzing the latest odds and matchups.

These college football best bets include matchups like the Iowa vs. Rutgers game at 8:00PM ET, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge college football bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Friday, September 19, 2025, including our full set of picks and best bets for today and the week ahead.

List of college football picks tonight [9/19, updated 7:03PM ET]

After crunching the numbers and running thousands of simulations, our famous predictive analytics model has figured out the best football bets for Friday, September 19, 2025.

Iowa vs. Rutgers under 46.5 points (-112)

• Probability: 56.5%
• Edge: 3.7%
• Matchup: Iowa vs. Rutgers (8:00PM ET, Friday)

Our model has pinpointed a high-probability college football betting opportunity tonight, which comes in the Iowa vs. Rutgers game. We recommend an over/under bet on under 46.5 points at -112 odds, with our analysis showing a 56.5% chance of hitting and a compelling edge of 3.7%.

Rutgers +2.5 (-108)

• Probability: 54.2%
• Edge: 2.3%
• Matchup: Iowa vs. Rutgers (8:00PM ET, Friday)

Our model has found another strong college football bet for Friday's sports action, again in the matchup between Iowa and Rutgers. We suggest placing a spread wager on Rutgers +2.5 at -108 odds, with a 54.2% probability delivering a 2.3% edge.

Rutgers ML (+114)

• Probability: 48.9%
• Edge: 2.2%
• Matchup: Iowa vs. Rutgers (8:00PM ET, Friday)

Our model has found another strong college football bet for tonight's college football action, also in the Iowa vs. Rutgers matchup. We recommend a bet on Rutgers ML at +114 odds. Our projections shows a 48.9% probability and 2.2% edge for this wager.

NCAAF best bets: Friday, 9/19/2025

As of 7:03PM ET, here are our top three college football bets by probability recommended by our model:

Matchup	Bet	Odds	Probability	Edge
Iowa vs. Rutgers	Under 46.5 Points	-112 @ DraftKings	56.5%	3.7%
Iowa vs. Rutgers	Rutgers +2.5	-108 @ DraftKings	54.2%	2.3%
Iowa vs. Rutgers	Rutgers ML	+114 @ DraftKings	48.9%	2.2%

The bets listed here are sorted by win probability—but the real path to profit lies in high-edge plays. Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Among today's NCAAF picks is a +165 moneyline bet with a 9.5% edge—the kind of high-upside play that makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for September 19, 2025.

List of upcoming college football games to bet on now

• Tulsa vs. Oklahoma State (7:30PM ET, Friday)
• Iowa vs. Rutgers (8:00PM ET, Friday)
• Texas Tech vs. Utah (12:00PM ET, Saturday)
• Southern Methodist vs. TCU (12:00PM ET, Saturday)
• Maryland vs. Wisconsin (12:00PM ET, Saturday)
• UNLV vs. Miami Ohio (12:00PM ET, Saturday)
• Bowling Green vs. Louisville (12:00PM ET, Saturday)
• Syracuse vs. Clemson (12:00PM ET, Saturday)
• North Texas vs. Army (12:00PM ET, Saturday)
• Arkansas vs. Memphis (12:00PM ET, Saturday)

More about college football

The bets on this page form part of our college football player props and college football best bets series.

For more NCAAF betting content, we have college football betting news and the latest National Championship odds and predictions.

Conclusion

Our college football best bets are locked and loaded for September 19, 2025, featuring plays such as under 46.5 points in the Iowa vs. Rutgers matchup and Rutgers +2.5. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate college football insights quickly, with human oversight ensuring high editorial quality. Our predictions are grounded in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

Note: Clicking links to our sportsbook partners may earn us a referral fee. Learn about how we review products and services.