College football picks today: Week 2 Saturday best bets include three moneyline plays [9/6/2025]

Today’s college football picks for September 6, 2025 are here, with Saturday’s college football best bets driven by tens of thousands of predictive simulations analyzing the latest odds and matchups.

These college football best bets include matchups like Houston vs. Rice and Richmond vs. Wofford, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge college football bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Saturday, September 6, 2025, including our full suite of picks and best bets for today and the week ahead.

List of college football picks today [9/6, updated 3:31PM ET]

After crunching the numbers and conducting thousands of simulations, our leading predictive analytics model has figured out the best football bets for Saturday, September 6, 2025.

Houston ML (-535)

• Probability: 87%
• Edge: 2.7%
• Matchup: Houston vs. Rice (7:00PM ET, Saturday)

Our model has pinpointed a high-probability college football betting opportunity today, which comes in the Houston vs. Rice matchup. We recommend a bet on the Houston ML at -535 odds, with our analysis showing a 87% chance of hitting and a compelling edge of 2.7%.

Richmond ML (-205)

• Probability: 69.6%
• Edge: 2.4%
• Matchup: Richmond vs. Wofford (6:00PM ET, Saturday)

Our model has found another strong college football bet for Saturday's sports action, this time in the matchup between Richmond and Wofford. We suggest placing a wager on Richmond ML at -205 odds, with a 69.6% probability delivering a 2.4% edge.

Alabama A&M ML (-176)

• Probability: 66%
• Edge: 2.2%
• Matchup: Alcorn State vs. Alabama A&M (7:00PM ET, Saturday)

Our model has found another strong college football bet for Saturday's college football action,this time in the Alcorn State vs. Alabama A&M matchup. We recommend a bet on Alabama A&M ML at -176 odds. Our model shows a 66% probability and 2.2% edge for this wager.

NCAAF best bets: Saturday, 9/6/2025

As of 3:31PM ET, here are our top three college football bets by probability recommended by our model:

Matchup	Bet	Odds	Probability	Edge
Houston vs. Rice	Houston ML	-535 @ DraftKings	87%	2.7%
Richmond vs. Wofford	Richmond ML	-205 @ DraftKings	69.6%	2.4%
Alcorn State vs. Alabama A&M	Alabama A&M ML	-176 @ FanDuel	66%	2.2%

The bets listed here are sorted by win probability—but the real path to profit lies in high-edge plays. Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Among today's NCAAF picks is a -110 over/under bet with a 10.3% edge—the kind of high-upside play that makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for September 6, 2025.

List of upcoming college football games to bet on now

• Middle Tennessee vs. Wisconsin (4:00PM ET, Saturday)
• West Virginia vs. Ohio (4:00PM ET, Saturday)
• Northern Iowa vs. Wyoming (4:00PM ET, Saturday)
• South Florida vs. Florida (4:15PM ET, Saturday)
• Arkansas State vs. Arkansas (5:00PM ET, Saturday)
• Utah Tech vs. Northern Arizona (5:00PM ET, Saturday)
• Sacramento State vs. Nevada (5:00PM ET, Saturday)
• Jackson State vs. Southern Miss (5:00PM ET, Saturday)
• Missouri State vs. Marshall (6:00PM ET, Saturday)
• Monmouth vs. Fordham (6:00PM ET, Saturday)

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More on college football

The best on this page form part of our college football player props and college football best bets series.

For more NCAAF betting content, we have college football betting news and the latest National Championship odds and predictions.

Conclusion

Our college football best bets are locked and loaded for September 6, 2025, featuring plays such as Houston ML and Richmond ML. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate college football insights quickly, with human oversight ensuring high editorial quality. Our predictions are based on current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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