College football picks today: Week 2 Friday best bets include Eastern Washington vs. Boise State play [9/5/2025]

Today’s college football picks for September 5, 2025 are here, with Friday’s college football best bets fueled by thousands of predictive simulations analyzing the latest odds and matchups.

These college football best bets include matchups like Eastern Washington vs. Boise State and Western Illinois vs. Northwestern, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

But if you're serious about long-term profit, it's not just about probability—it's about edge. To unlock our highest-edge college football bets—the ones with true long-term value—join Dimers Pro.

Pro members get unlimited access to everything Dimers has to offer on Friday, September 5, 2025, including our full set of picks and best bets for today and the week ahead.

List of college football picks tonight [9/5, updated 7:02PM ET]

After digging deep into the numbers and conducting thousands of simulations, our independent predictive analytics model has figured out the best football bets for Friday, September 5, 2025.

Eastern Washington vs. Boise State over 59.5 points (-110)

• Probability: 58%
• Edge: 5.6%
• Matchup: Eastern Washington vs. Boise State (9:00PM ET, Friday)

Our model has pinpointed a high-probability college football betting opportunity tonight, which comes in the Eastern Washington vs. Boise State game. We recommend an over/under bet on over 59.5 points at -110 odds, with our analysis showing a 58% chance of hitting and a compelling edge of 5.6%.

Western Illinois +31.5 (-110)

• Probability: 54.5%
• Edge: 2.1%
• Matchup: Western Illinois vs. Northwestern (7:30PM ET, Friday)

Our model has found another strong college football bet for Friday's sports action, this time in the matchup between Western Illinois and Northwestern. We suggest placing a spread wager on Western Illinois +31.5 at -110 odds, with a 54.5% probability delivering a 2.1% edge.

NCAAF best bets: Friday, 9/5/2025

As of 7:02PM ET, here are our top two college football bets by probability recommended by our model:

Matchup	Bet	Odds	Probability	Edge
Eastern Washington vs. Boise State	Over 59.5 Points	-110 @ DraftKings	58%	5.6%
Western Illinois vs. Northwestern	Western Illinois +31.5	-110 @ BetMGM	54.5%	2.1%

The bets listed here are sorted by win probability—but the real path to profit lies in high-edge plays. Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Among today's NCAAF picks is a +145 moneyline bet with a 9.1% edge—the kind of high-upside play that makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for September 5, 2025.

List of upcoming college football games to bet on now

• Northern Illinois vs. Maryland (7:30PM ET, Friday)
• Western Illinois vs. Northwestern (7:30PM ET, Friday)
• Eastern Washington vs. Boise State (9:00PM ET, Friday)
• Baylor vs. Southern Methodist (12:00PM ET, Saturday)
• Illinois vs. Duke (12:00PM ET, Saturday)
• Iowa vs. Iowa State (12:00PM ET, Saturday)
• Virginia vs. North Carolina State (12:00PM ET, Saturday)
• San Jose State vs. Texas (12:00PM ET, Saturday)
• Florida International vs. Penn State (12:00PM ET, Saturday)
• Kent State vs. Texas Tech (12:00PM ET, Saturday)

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More on college football

The best on this page form part of our college football player props and college football best bets series.

For more NCAAF betting content, we have college football betting news and the latest National Championship odds and predictions.

Conclusion

Our college football best bets are locked and loaded for September 5, 2025, featuring plays such as over 59.5 points in the Eastern Washington vs. Boise State matchup and Western Illinois +31.5. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate college football insights quickly, with human oversight ensuring high editorial quality. Our predictions are rooted in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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