Colgate vs. Villanova prediction: Villanova favored to win in college football Week 2, 2025

Villanova will face Colgate in Week 2 college football action at Villanova Stadium on Saturday, starting at 6:00PM ET.

Based on the latest simulations, Dimers' proven college football model predicts Villanova as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Colgate vs. Villanova predictions page.

Colgate vs. Villanova prediction: Who will win, cover the spread?

Using innovative machine learning and data, we have simulated the outcome of Colgate vs. Villanova 10,000 times as part of our college football predictions coverage.

Our famous predictive model gives Villanova a 90% chance of defeating Colgate. Our predicted final score has Villanova winning 35-16.

According to our model, the bookmakers have got it right, and Colgate and Villanova each have a 50% chance of covering the spread, while the 50.5-point over/under has a 56% chance of staying under.

Colgate vs. Villanova odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Colgate	Villanova
Spread	+19.5 (-105)	-19.5 (-110)
Moneyline	+800	-1000
Total	o50.5 (-105)	u50.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Colgate vs. Villanova picks and best bets

Our model's strongest edge in today's Colgate vs. Villanova matchup is on the spread.

Our expert predictions, matched against the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Colgate vs. Villanova game-day updates and essential details

Saturday's college football matchup between Villanova and Colgate at Villanova Stadium is scheduled to begin at 6:00PM ET.

• Who: Colgate vs. Villanova
• Date: Saturday, September 6, 2025
• Time: 6:00PM ET/3:00PM PT
• Venue: Villanova Stadium

Dimers.com's comprehensive preview of Saturday's Colgate vs. Villanova matchup includes our prediction, picks and the latest betting odds.

Before making any Colgate vs. Villanova picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Villanova, with a 90% win probability, will likely beat Colgate on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Colgate vs. Villanova insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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