Colgate vs. Syracuse prediction: Syracuse favored to win in college football Week 3, 2025

Syracuse and Colgate will meet in Week 3 college football action at JMA Wireless Dome on Friday, starting at 7:00PM ET.

Based on updated simulations, Dimers' proven college football model predicts Syracuse as the most likely winner of today's game.

For further insights into Friday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Colgate vs. Syracuse predictions page.

Colgate vs. Syracuse prediction: Who will win, cover the spread?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Colgate vs. Syracuse 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives Syracuse a 98% chance of beating Colgate. Our predicted final score has Syracuse winning 49-13.

According to our model, the bookies have got it right, and Colgate and Syracuse each have a 50% chance of covering the spread, while the over/under total of 64.5 points has a 54% chance of going over.

Colgate vs. Syracuse odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Colgate	Syracuse
Spread	+36.5 (-102)	-36.5 (-115)
Moneyline	+5500	-50000
Total	o64.5 (-110)	u64.5 (-105)

All odds are correct at the time of publication and are subject to change.

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Colgate vs. Syracuse picks and best bets

Our model's biggest edge in today's Colgate vs. Syracuse matchup is on the spread.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Colgate vs. Syracuse game-day updates and essential details

Friday's college football matchup between Syracuse and Colgate at JMA Wireless Dome is scheduled to commence at 7:00PM ET.

• Who: Colgate vs. Syracuse
• Date: Friday, September 12, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: JMA Wireless Dome

Dimers' comprehensive preview of Friday's Colgate vs. Syracuse matchup includes our prediction, picks and the latest betting odds.

Before making any Colgate vs. Syracuse picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Syracuse, with a 98% win probability, will likely beat Colgate on Friday.

AI and automation have enhanced this article to quickly deliver accurate Colgate vs. Syracuse insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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