Club America vs. Guadalajara prediction, odds, Liga MX picks [9/13/2025]

Club America will face Guadalajara in Liga MX action at Estadio Ciudad de los Deportes on Saturday, starting at 11:15PM ET.

Based on the latest simulations, Dimers' advanced Liga MX model predicts Club America as the most likely winner of today's game.

For a closer look at Saturday's matchup, including best bets and picks, visit our interactive Club America vs. Guadalajara predictions page.

Club America vs. Guadalajara prediction: Who will win?

Using powerful machine learning and data analysis, we have simulated the outcome of Saturday's Liga MX game between Club America and Guadalajara 10,000 times as part of our Liga MX predictions coverage.

Our famous predictive model indicates a 58.7% chance of Club America winning, an 18.6% chance for Guadalajara, and a 22.7% chance of a draw.

Additionally, the over/under total of 2.5 goals has a 51% chance of staying under, according to our model.

Club America vs. Guadalajara odds

We have researched the best Liga MX odds in America for this game, which are listed here:

Moneyline

Club America	Guadalajara	Draw
-140	+390	+280

Total Goals

Over 2.5	Under 2.5
-135	+114

All odds are correct at the time of publication and are subject to change.

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Club America vs. Guadalajara picks and best bets

Our model's strongest edge in today's Club America vs. Guadalajara matchup is on the total.

Our expert predictions, matched against the current odds, reveal the best Liga MX picks and Liga MX best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Club America vs. Guadalajara: Correct score and BTTS predictions

Here are the top three most likely final scores according to our model, with a 1-0 Club America win being the most probable:

Final Score	Probability
AME 1-0 GUA	11.8%
AME 1-1 GUA	10.8%
AME 2-0 GUA	10.7%

When it comes to the both teams to score (BTTS) market, we project a 50.4% chance of the yes hitting, and a 49.6% probability of at least one team being held goalless.

These predictions are based on each team's average score after 10,000 simulations.

Club America vs. Guadalajara game-day updates and essential details

Saturday's matchup between Club America and Guadalajara at Estadio Ciudad de los Deportes is scheduled to start at 11:15PM ET.

• Who: Club America vs. Guadalajara
• Date: Saturday, September 13, 2025
• Time: 11:15PM ET/8:15PM PT
• Venue: Estadio Ciudad de los Deportes

Dimers' comprehensive preview of Saturday's Club America vs. Guadalajara matchup includes our prediction, picks and the latest betting odds.

Before making any Guadalajara vs. Club America picks, be sure to check out the latest Liga MX predictions and betting advice from Dimers Pro.

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Conclusion

According to our computer model, Club America has a 58.7% win probability on Saturday, Guadalajara has an 18.6% win probability, and there is a 22.7% chance that the game will end in a draw.

AI and automation have enhanced this article to quickly deliver accurate Club America vs. Guadalajara insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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