Guardians vs. Nationals Prediction: Tight Battle Projected in Updated Analysis for Monday's MLB Matchup [5/5/2025]

The Washington Nationals will square off with the Cleveland Guardians in MLB action at Nationals Park on Monday, starting at 6:45PM ET.

The Nationals will have Jake Irvin (2-1, 4.01 ERA) as their starting pitcher, while the Guardians will counter with Luis L. Ortiz (2-3, 4.78 ERA).

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts an equal chance for both the Nationals and Guardians to win today's game.

"Our team has utilized the latest data to simulate Monday's Cleveland-Washington game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Based on the latest updates and extensive data, we predict a 50-50 chance for both the Nationals and Guardians, making it a highly competitive matchup."

For expanded analysis of Monday's matchup, including best bets and picks, visit our interactive Guardians vs. Nationals predictions page.

Nationals vs. Guardians Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the outcome of Monday's MLB game between the Guardians and Nationals 10,000 times as part of our MLB predictions coverage.

Our famous predictive model can't split the two teams, giving both the Guardians and Nationals a 50% chance of winning the game.

According to our model, the Nationals (+1.5) have a 63% chance of covering the run line, while the 9-run over/under has a 55% chance of staying under.

Guardians vs. Nationals Odds [5/5/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Guardians	Nationals
Run Line	-1.5 (+138)	+1.5 (-155)
Moneyline	-120	+105
Total	o9 (+100)	u9 (-112)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Guardians vs. Nationals Picks and Best Bets

Our model's strongest edge in today's Guardians vs. Nationals matchup is on the over/under.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Guardians vs. Nationals Game-Day Updates and Essential Details

Monday's MLB action between the Nationals and Guardians at Nationals Park is scheduled to commence at 6:45PM ET.

• Who: Cleveland Guardians vs. Washington Nationals
• Date: Monday, May 5, 2025
• Time: 6:45PM ET/3:45PM PT
• Venue: Nationals Park

Dimers.com's in-depth preview of Monday's Guardians vs. Nationals matchup includes our prediction, picks and the latest betting odds.

Before making any Cleveland vs. Washington picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Conclusion

We predict a close game between the Guardians and Nationals on Monday, with each team having a 50% chance of winning.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Nationals insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay up-to-date with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds offer the most accurate probabilities for the World Series, American League, National League and each division.