Guardians vs. Rays prediction: Why Tampa Bay is favored to win Thursday's MLB matchup [9/4/2025]

The Tampa Bay Rays will face the Cleveland Guardians in MLB action at George M. Steinbrenner Field on Thursday, beginning at 7:35PM ET.

Ryan Pepiot (10-10, 3.70 ERA) will start on the mound for the Rays, pitting him against Logan Allen (7-10, 4.42 ERA) for the Guardians.

Based on updated simulations, Dimers' advanced MLB model projects the Rays as the most likely winner of today's game.

For a closer look at Thursday's matchup, including best bets and picks, visit our interactive Guardians vs. Rays predictions page.

Rays vs. Guardians prediction: Who will win, cover the run line?

Using innovative machine learning and statistical analysis, we have simulated the result of Thursday's MLB game between the Guardians and Rays 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Rays a 59% chance of defeating the Guardians.

According to our model, the Guardians (+1.5) have a 60% chance of covering the run line, while the over/under total of 8.5 runs has a 52% chance of staying under.

Guardians vs. Rays odds [9/4/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Guardians	Rays
Run Line	+1.5 (-149)	-1.5 (+126)
Moneyline	+140	-162
Total	o8.5 (-105)	u8.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Guardians vs. Rays picks and best bets

Our model's biggest edge in today's Guardians vs. Rays matchup is on the total.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets today

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Guardians vs. Rays game-day updates and essential details

Thursday's MLB game between the Rays and Guardians at George M. Steinbrenner Field is scheduled to begin at 7:35PM ET.

• Who: Cleveland Guardians vs. Tampa Bay Rays
• Date: Thursday, September 4, 2025
• Time: 7:35PM ET/4:35PM PT
• Venue: George M. Steinbrenner Field

Dimers.com's full preview of Thursday's Guardians vs. Rays matchup includes our prediction, picks and the latest betting odds.

Before making any Guardians vs. Rays picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Rays, with a 59% win probability, will likely beat the Guardians on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Rays insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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