Guardians vs. Rays prediction: Why Tampa Bay is favored to win Thursday's MLB matchup [9/4/2025]

The Tampa Bay Rays and Cleveland Guardians will lock horns in MLB action at George M. Steinbrenner Field on Thursday, starting at 7:35PM ET.

The Rays will start Ryan Pepiot (10-10, 3.70 ERA), while the Guardians will counter with Logan Allen (7-10, 4.42 ERA).

Based on updated simulation results, Dimers' advanced MLB model predicts the Rays as the most likely winner of today's game.

For expanded analysis of Thursday's matchup, including best bets and picks, visit our interactive Guardians vs. Rays predictions page.

Rays vs. Guardians prediction: Who will win, cover the run line?

Using innovative machine learning and data, we have simulated the outcome of Thursday's MLB matchup between the Guardians and Rays 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Rays a 59% chance of defeating the Guardians.

According to our model, the Guardians (+1.5) have a 60% chance of covering the run line, while the 8.5-run over/under has a 52% chance of staying under.

Guardians vs. Rays odds [9/4/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Guardians	Rays
Run Line	+1.5 (-149)	-1.5 (+126)
Moneyline	+140	-162
Total	o8.5 (-105)	u8.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Guardians vs. Rays picks and best bets

Our model's biggest edge in today's Guardians vs. Rays matchup is on the over/under.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets video

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Guardians vs. Rays game-day updates and essential details

Thursday's MLB matchup between the Rays and Guardians at George M. Steinbrenner Field is scheduled to commence at 7:35PM ET.

• Who: Cleveland Guardians vs. Tampa Bay Rays
• Date: Thursday, September 4, 2025
• Time: 7:35PM ET/4:35PM PT
• Venue: George M. Steinbrenner Field

Dimers.com's comprehensive preview of Thursday's Guardians vs. Rays matchup includes our prediction, picks and the latest betting odds.

Before making any Guardians vs. Rays picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Rays, with a 59% win probability, will likely beat the Guardians on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Rays insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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