Guardians vs. Rays prediction: Why Tampa Bay is favored to win Friday's MLB matchup [9/5/2025]

The Tampa Bay Rays and Cleveland Guardians are scheduled to meet in MLB action at George M. Steinbrenner Field on Friday, starting at 7:35PM ET.

Griffin Jax (1-7, 4.98 ERA) will be the starting pitcher for the Rays, up against Gavin Williams (9-5, 3.26 ERA) for the Guardians.

Based on updated simulations, Dimers' advanced MLB model predicts the Rays as the most likely winner of today's game.

For a closer look at Friday's matchup, including best bets and picks, visit our interactive Guardians vs. Rays predictions page.

Rays vs. Guardians prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the result of Friday's MLB matchup between the Guardians and Rays 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Rays a 57% chance of defeating the Guardians.

According to our model, the Guardians (+1.5) have a 62% chance of covering the run line, while the over/under total of 7.5 runs has a 53% chance of going over.

Guardians vs. Rays odds [9/5/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Guardians	Rays
Run Line	+1.5 (-170)	-1.5 (+152)
Moneyline	+130	-148
Total	o7.5 (+103)	u7.5 (-120)

All odds are correct at the time of publication and are subject to change.

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Guardians vs. Rays picks and best bets

Our model's biggest edge in today's Guardians vs. Rays matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

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Guardians vs. Rays game-day updates and essential details

Friday's MLB action between the Rays and Guardians at George M. Steinbrenner Field is scheduled to start at 7:35PM ET.

• Who: Cleveland Guardians vs. Tampa Bay Rays
• Date: Friday, September 5, 2025
• Time: 7:35PM ET/4:35PM PT
• Venue: George M. Steinbrenner Field

Dimers.com's comprehensive preview of Friday's Guardians vs. Rays matchup includes our prediction, picks and the latest betting odds.

Before making any Guardians vs. Rays picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Rays, with a 57% win probability, will likely beat the Guardians on Friday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Rays insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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