Guardians vs. Giants Prediction: San Francisco Predicted to Win Wednesday's MLB Matchup [6/18/2025]

The San Francisco Giants will take on the Cleveland Guardians in MLB action at Oracle Park on Wednesday, beginning at 9:45PM ET.

Justin Verlander (0-3, 4.33 ERA) will start for the Giants, up against Logan Allen (4-4, 4.28 ERA) for the Guardians.

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Giants as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Cleveland-San Francisco game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Giants' chance of winning at 56%, with the Guardians at 44%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Guardians vs. Giants predictions page.

Giants vs. Guardians Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Wednesday's MLB matchup between the Guardians and Giants 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Giants a 56% chance of defeating the Guardians.

According to our model, the Guardians (+1.5) have a 63% chance of covering the run line, while the 8.5-run over/under has a 54% chance of staying under.

Guardians vs. Giants Odds [6/18/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Guardians	Giants
Run Line	+1.5 (-162)	-1.5 (+145)
Moneyline	+133	-150
Total	o8.5 (-102)	u8.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Guardians vs. Giants Picks and Best Bets

Our model's strongest edge in today's Guardians vs. Giants matchup is on the total.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Guardians vs. Giants Game-Day Updates and Essential Details

Wednesday's MLB game between the Giants and Guardians at Oracle Park is scheduled to start at 9:45PM ET.

• Who: Cleveland Guardians vs. San Francisco Giants
• Date: Wednesday, June 18, 2025
• Time: 9:45PM ET/6:45PM PT
• Venue: Oracle Park

Dimers.com's in-depth preview of Wednesday's Guardians vs. Giants matchup includes our prediction, picks and the latest betting odds.

Before making any Cleveland vs. San Francisco picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Giants, with a 56% win probability, will likely beat the Guardians on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Giants insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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