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Guardians vs. Yankees Prediction: Yankees Predicted to Win Wednesday's MLB Matchup [6/4/2025]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Our expert prediction for Wednesday's Cleveland Guardians vs New York Yankees matchup.
The New York Yankees will square off with the Cleveland Guardians in MLB action at Yankee Stadium on Wednesday, commencing at 7:05PM ET.
The Yankees will start Clarke Schmidt (2-2, 3.95 ERA), pitting him against Luis L. Ortiz (2-6, 4.40 ERA) for the Guardians.
Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Yankees as the most likely winner of today's game.
"Our team has simulated the outcome of Wednesday's Cleveland-NY Yankees game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.
"With the latest updates and numerous other variables, we estimate the Yankees' chance of winning at 62%, with the Guardians at 38%."
For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Guardians vs. Yankees predictions page.
Yankees vs. Guardians Prediction: Who Will Win, Cover the Run Line?
Using innovative machine learning and statistical analysis, we have simulated the outcome of Wednesday's MLB matchup between the Guardians and Yankees 10,000 times as part of our MLB predictions coverage.
Our independent predictive model gives the Yankees a 62% chance of defeating the Guardians.
According to our model, the Guardians (+1.5) have a 56% chance of covering the run line, while the 9-run over/under has a 53% chance of staying under.
Guardians vs. Yankees Odds [6/4/2025]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Guardians | Yankees |
|---|---|---|
| Run Line | +1.5 (-118) | -1.5 (+105) |
| Moneyline | +164 | -190 |
| Total | o9 (-102) | u9 (-118) |
All odds are correct at the time of publication and are subject to change.
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Guardians vs. Yankees Picks and Best Bets
Our model's strongest edge in today's Guardians vs. Yankees matchup is on the over/under.
Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.
Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.
Calling Our Shot's Free ⚾️ Picks
Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.
Guardians vs. Yankees Game-Day Updates and Essential Details
Wednesday's MLB action between the Yankees and Guardians at Yankee Stadium is scheduled to commence at 7:05PM ET.
- Who: Cleveland Guardians vs. New York Yankees
- Date: Wednesday, June 4, 2025
- Time: 7:05PM ET/4:05PM PT
- Venue: Yankee Stadium
Dimers.com's full preview of Wednesday's Guardians vs. Yankees matchup includes our prediction, picks and the latest betting odds.
Before making any Cleveland vs. NY Yankees picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.
Key MLB Betting Guides and Insights
- Explore how MLB odds work and dive into MLB live betting strategies
- Understand where sports odds come from and how they're applied to baseball matchups
- Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
- Stay informed with where online sports betting is currently legal and which betting sites are safest to use
- Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on
Conclusion
We predict the Yankees, with a 62% win probability, will likely beat the Guardians on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Yankees insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Keep up with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds offer the latest predictions for the World Series, American League, National League and each division.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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