Guardians vs. Yankees Prediction: Yankees Predicted to Win Thursday's MLB Matchup [6/5/2025]

The New York Yankees and Cleveland Guardians will meet in MLB action at Yankee Stadium on Thursday, starting at 7:05PM ET.

Max Fried (7-1, 1.92 ERA) will start for the Yankees, up against Slade Cecconi (1-1, 5.28 ERA) for the Guardians.

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Yankees as the most likely winner of today's game.

"Using the latest data, our experts simulated Thursday's Cleveland-NY Yankees game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Taking into account recent updates and various additional inputs, we forecast the Yankees with a win probability of 68% and the Guardians with 32%."

For expanded analysis of Thursday's matchup, including best bets and picks, visit our interactive Guardians vs. Yankees predictions page.

Yankees vs. Guardians Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Thursday's MLB game between the Guardians and Yankees 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Yankees a 68% chance of defeating the Guardians.

According to our model, the bookmakers have got it right, and the Guardians and Yankees each have a 50% chance of covering the run line, while the over/under total of 8.5 runs has a 54% chance of staying under.

Guardians vs. Yankees Odds [6/5/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Guardians	Yankees
Run Line	+1.5 (+114)	-1.5 (-130)
Moneyline	+225	-275
Total	o8.5 (-102)	u8.5 (-112)

All odds are correct at the time of publication and are subject to change.

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Guardians vs. Yankees Picks and Best Bets

Our model's biggest edge in today's Guardians vs. Yankees matchup is on the over/under.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Guardians vs. Yankees Game-Day Updates and Essential Details

Thursday's MLB game between the Yankees and Guardians at Yankee Stadium is scheduled to begin at 7:05PM ET.

• Who: Cleveland Guardians vs. New York Yankees
• Date: Thursday, June 5, 2025
• Time: 7:05PM ET/4:05PM PT
• Venue: Yankee Stadium

Dimers.com's in-depth preview of Thursday's Guardians vs. Yankees matchup includes our prediction, picks and the latest betting odds.

Before making any Cleveland vs. NY Yankees picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Yankees, with a 68% win probability, will likely beat the Guardians on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Yankees insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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