Guardians vs. Twins prediction: Why Cleveland is favored to win Sunday's MLB matchup [9/21/2025]

MLB action continues on Sunday at 2:10PM ET as the Cleveland Guardians square off with the Minnesota Twins at Target Field.

The Twins will start Simeon Woods Richardson (7-4, 4.31 ERA), up against Joey Cantillo (5-3, 3.27 ERA) for the Guardians.

Based on updated simulation results, Dimers' proven MLB model projects the Guardians as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Guardians-Twins game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Guardians with a win probability of 55%, while the Twins have 45%."

For a closer look at Sunday's matchup, including best bets and picks, visit our interactive Guardians vs. Twins predictions page.

Twins vs. Guardians prediction: Who will win, cover the run line?

Using innovative machine learning and data, we have simulated the result of Sunday's MLB matchup between the Guardians and Twins 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Guardians a 55% chance of beating the Twins.

According to our model, the Twins (+1.5) have a 58% chance of covering the run line, while the 8.5-run over/under has a 54% chance of going over.

Guardians vs. Twins odds [9/21/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Guardians	Twins
Run Line	-1.5 (+118)	+1.5 (-134)
Moneyline	-143	+122
Total	o8.5 (-102)	u8.5 (-104)

All odds are correct at the time of publication and are subject to change.

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Guardians vs. Twins picks and best bets

Our model's biggest edge in today's Guardians vs. Twins matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Guardians vs. Twins game-day updates and essential details

Sunday's MLB game between the Twins and Guardians at Target Field is scheduled to begin at 2:10PM ET.

• Who: Cleveland Guardians vs. Minnesota Twins
• Date: Sunday, September 21, 2025
• Time: 2:10PM ET/11:10AM PT
• Venue: Target Field

Dimers' comprehensive preview of Sunday's Guardians vs. Twins matchup includes our prediction, picks and the latest betting odds.

Before making any Guardians vs. Twins picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Guardians, with a 55% win probability, will likely beat the Twins on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Twins insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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