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Guardians vs. Twins prediction: Why Minnesota is favored to win Friday's MLB matchup [9/19/2025]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get Cleveland Guardians vs Minnesota Twins predictions for MLB Friday.
The Minnesota Twins will square off with the Cleveland Guardians, in what is expected to be a tight MLB game, at Target Field on Friday, beginning at 8:10PM ET.
Pablo López (5-4, 2.64 ERA) will start for the Twins, up against Parker Messick (3-0, 1.84 ERA) for the Guardians.
Based on the latest simulations, Dimers' proven MLB model predicts the Twins as the most likely winner of today's game.
For a closer look at Friday's matchup, including best bets and picks, visit our interactive Guardians vs. Twins predictions page.
Twins vs. Guardians prediction: Who will win, cover the run line?
Using trusted machine learning and data, we have simulated the result of Friday's MLB matchup between the Guardians and Twins 10,000 times as part of our MLB predictions coverage.
Our famous predictive model gives the Twins a 51% chance of defeating the Guardians.
According to our model, the Twins (+1.5) have a 67% chance of covering the run line, while the over/under total of 7.5 runs has a 57% chance of going over.
Guardians vs. Twins odds [9/19/2025]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Guardians | Twins |
|---|---|---|
| Run Line | -1.5 (+148) | +1.5 (-176) |
| Moneyline | -105 | -104 |
| Total | o7.5 (-120) | u7.5 (-102) |
All odds are correct at the time of publication and are subject to change.
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Guardians vs. Twins picks and best bets
Our model's strongest edge in today's Guardians vs. Twins matchup is on the over/under.
Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.
Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.
Calling Our Shot's best bets
Calling Our Shot produces daily MLB betting content, including the best bets featured below.
Guardians vs. Twins game-day updates and essential details
Friday's MLB action between the Twins and Guardians at Target Field is scheduled to begin at 8:10PM ET.
- Who: Cleveland Guardians vs. Minnesota Twins
- Date: Friday, September 19, 2025
- Time: 8:10PM ET/5:10PM PT
- Venue: Target Field
Dimers' in-depth preview of Friday's Guardians vs. Twins matchup includes our prediction, picks and the latest betting odds.
Before making any Guardians vs. Twins picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.
Conclusion
We predict the Twins, with a 51% win probability, will likely beat the Guardians on Friday.
AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Twins insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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