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Guardians vs. Twins Prediction: Minnesota Predicted to Win Wednesday's MLB Matchup [5/21/2025]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Our expert prediction for Wednesday's Cleveland Guardians vs Minnesota Twins matchup.
The Minnesota Twins will square off with the Cleveland Guardians in MLB action at Target Field on Wednesday, commencing at 1:10PM ET.
Joe Ryan (4-2, 2.42 ERA) will get the ball for the Twins, while the Guardians have opted for Tanner Bibee (3-4, 4.06 ERA).
Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Twins as the most likely winner of today's game.
"Our team has simulated the outcome of Wednesday's Cleveland-Minnesota game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.
"With the latest updates and numerous other variables, we estimate the Twins' chance of winning at 57%, with the Guardians at 43%."
For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Guardians vs. Twins predictions page.
Twins vs. Guardians Prediction: Who Will Win?
Using powerful machine learning and data analysis, we have simulated the outcome of Wednesday's MLB matchup between the Guardians and Twins 10,000 times as part of our MLB predictions coverage.
Our independent predictive model gives the Twins a 57% chance of beating the Guardians.
According to our model, the over/under total of 7.5 runs has a 51% chance of going over.
Guardians vs. Twins Odds [5/21/2025]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Guardians | Twins |
|---|---|---|
| Moneyline | +102 | -118 |
| Total | o7.5 (-102) | u7.5 (-118) |
All odds are correct at the time of publication and are subject to change.
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Guardians vs. Twins Picks and Best Bets
Our model's strongest edge in today's Guardians vs. Twins matchup is on the moneyline.
Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.
Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.
Calling Our Shot's Free ⚾️ Picks
Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.
Guardians vs. Twins Game-Day Updates and Essential Details
Wednesday's MLB matchup between the Twins and Guardians at Target Field is scheduled to start at 1:10PM ET.
- Who: Cleveland Guardians vs. Minnesota Twins
- Date: Wednesday, May 21, 2025
- Time: 1:10PM ET/10:10AM PT
- Venue: Target Field
Dimers.com's in-depth preview of Wednesday's Guardians vs. Twins matchup includes our prediction, picks and the latest betting odds.
Before making any Cleveland vs. Minnesota picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.
Key MLB Betting Guides and Insights
- Explore how MLB odds work and dive into MLB live betting strategies
- Understand where sports odds come from and how they're applied to baseball matchups
- Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
- Stay informed with where online sports betting is currently legal and which betting sites are safest to use
- Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on
Conclusion
We predict the Twins, with a 57% win probability, will likely beat the Guardians on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Twins insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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More on MLB
Stay up-to-date with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds provide the most up-to-date predictions for the World Series, American League, National League and each division.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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