Guardians vs. Twins Prediction: Minnesota Predicted to Win Tuesday's MLB Matchup [5/20/2025]

The Minnesota Twins and Cleveland Guardians will lock horns in MLB action at Target Field on Tuesday, starting at 6:10PM ET.

The Twins will have Bailey Ober (4-1, 3.72 ERA) as their starting pitcher, pitting him against Logan Allen (2-2, 3.70 ERA) for the Guardians.

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Twins as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's Cleveland-Minnesota game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Twins with a win probability of 65%, compared to 35% for the Guardians."

For further insights into Tuesday's matchup, including best bets and picks, visit our interactive Guardians vs. Twins predictions page.

Twins vs. Guardians Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the result of Tuesday's MLB matchup between the Guardians and Twins 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Twins a 65% chance of beating the Guardians.

According to our model, the Guardians (+1.5) have a 68% chance of covering the run line, while the over/under total of 7.5 runs has a 51% chance of going over.

Guardians vs. Twins Odds [5/20/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Guardians	Twins
Run Line	+1.5 (-250)	-1.5 (+185)
Moneyline	+100	-115
Total	o7.5 (-102)	u7.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Guardians vs. Twins Picks and Best Bets

Our model's strongest edge in today's Guardians vs. Twins matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Guardians vs. Twins Game-Day Updates and Essential Details

Tuesday's MLB matchup between the Twins and Guardians at Target Field is scheduled to commence at 6:10PM ET.

• Who: Cleveland Guardians vs. Minnesota Twins
• Date: Tuesday, May 20, 2025
• Time: 6:10PM ET/3:10PM PT
• Venue: Target Field

Dimers.com's comprehensive preview of Tuesday's Guardians vs. Twins matchup includes our prediction, picks and the latest betting odds.

Before making any Cleveland vs. Minnesota picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Twins, with a 65% win probability, will likely beat the Guardians on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Twins insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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