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Guardians vs. Twins Prediction: Minnesota Predicted to Win Monday's MLB Matchup [5/19/2025]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Our expert prediction for Monday's Cleveland Guardians vs Minnesota Twins matchup.
The Minnesota Twins will take on the Cleveland Guardians in MLB action at Target Field on Monday, starting at 7:40PM ET.
Bailey Ober (4-1, 3.72 ERA) will be on the bump for the Twins, while the Guardians are going with Logan Allen (2-2, 3.70 ERA).
Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Twins as the most likely winner of today's game.
"Our team has utilized the latest data to simulate Monday's Cleveland-Minnesota game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.
"Incorporating recent updates and thousands of additional inputs, our prediction shows the Twins are likely to win, with a probability of 56%, compared to the Guardians' 44%."
For expanded analysis of Monday's matchup, including best bets and picks, visit our interactive Guardians vs. Twins predictions page.
Twins vs. Guardians Prediction: Who Will Win, Cover the Run Line?
Using innovative machine learning and statistical analysis, we have simulated the result of Monday's MLB game between the Guardians and Twins 10,000 times as part of our MLB predictions coverage.
Our leading predictive model gives the Twins a 56% chance of beating the Guardians.
According to our model, the Guardians (+1.5) have a 62% chance of covering the run line, while the over/under total of 7.5 runs has a 52% chance of going over.
Guardians vs. Twins Odds [5/19/2025]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Guardians | Twins |
|---|---|---|
| Run Line | +1.5 (-164) | -1.5 (+145) |
| Moneyline | +124 | -144 |
| Total | o7.5 (-115) | u7.5 (-102) |
All odds are correct at the time of publication and are subject to change.
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Guardians vs. Twins Picks and Best Bets
Our model's strongest edge in today's Guardians vs. Twins matchup is on the over/under.
Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.
Unlimited access to our full set of picks, including this one, is available via Dimers Pro.
Calling Our Shot's Best Bets Video
Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.
Guardians vs. Twins Game-Day Updates and Essential Details
Monday's MLB game between the Twins and Guardians at Target Field is scheduled to start at 7:40PM ET.
- Who: Cleveland Guardians vs. Minnesota Twins
- Date: Monday, May 19, 2025
- Time: 7:40PM ET/4:40PM PT
- Venue: Target Field
Dimers.com's comprehensive preview of Monday's Guardians vs. Twins matchup includes our prediction, picks and the latest betting odds.
Before making any Cleveland vs. Minnesota picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.
Key MLB Betting Guides and Insights
- Explore how MLB odds work and dive into MLB live betting strategies
- Understand where sports odds come from and how they're applied to baseball matchups
- Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
- Stay informed with where online sports betting is currently legal and which betting sites are safest to use
- Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on
Conclusion
We predict the Twins, with a 56% win probability, will likely beat the Guardians on Monday.
AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Twins insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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