Guardians vs. Astros Prediction: Houston Predicted to Win Wednesday's MLB Matchup [7/9/2025]

The Houston Astros will face the Cleveland Guardians in MLB action at Daikin Park on Wednesday, starting at 8:10PM ET.

The Astros will start Brandon Walter (1-1, 4.15 ERA), pitting him against Slade Cecconi (3-4, 3.56 ERA) for the Guardians.

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Astros as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Guardians-Astros game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Astros' chance of winning at 59%, with the Guardians at 41%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Guardians vs. Astros predictions page.

Astros vs. Guardians Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data analysis, we have simulated the result of Wednesday's MLB matchup between the Guardians and Astros 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Astros a 59% chance of beating the Guardians.

According to our model, the Guardians (+1.5) have a 61% chance of covering the run line, while the 7.5-run over/under has a 51% chance of staying under.

Guardians vs. Astros Odds [7/9/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Guardians	Astros
Run Line	+1.5 (-180)	-1.5 (+150)
Moneyline	+140	-154
Total	o7.5 (+101)	u7.5 (-120)

All odds are correct at the time of publication and are subject to change.

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Guardians vs. Astros Picks and Best Bets

Our model's strongest edge in today's Guardians vs. Astros matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Guardians vs. Astros Game-Day Updates and Essential Details

Wednesday's MLB action between the Astros and Guardians at Daikin Park is scheduled to commence at 8:10PM ET.

• Who: Cleveland Guardians vs. Houston Astros
• Date: Wednesday, July 9, 2025
• Time: 8:10PM ET/5:10PM PT
• Venue: Daikin Park

Dimers.com's full preview of Wednesday's Guardians vs. Astros matchup includes our prediction, picks and the latest betting odds.

Before making any Guardians vs. Astros picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Astros, with a 59% win probability, will likely beat the Guardians on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Astros insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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