MLB- More Betting
Guardians vs. Astros Prediction: Houston Predicted to Win Monday's MLB Matchup [7/7/2025]
Our expert prediction for Monday's Cleveland Guardians vs Houston Astros matchup.

The Houston Astros will take on the Cleveland Guardians in MLB action at Daikin Park on Monday, commencing at 8:10PM ET.
The Astros will start Colton Gordon (3-1, 4.37 ERA), while the Guardians have opted for Tanner Bibee (4-9, 4.20 ERA).
Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Astros as the most likely winner of today's game.
For a closer look at Monday's matchup, including best bets and picks, visit our interactive Guardians vs. Astros predictions page.
Astros vs. Guardians Prediction: Who Will Win, Cover the Run Line?
Using powerful machine learning and data analysis, we have simulated the result of Monday's MLB matchup between the Guardians and Astros 10,000 times as part of our MLB predictions coverage.
Our famous predictive model gives the Astros a 55% chance of beating the Guardians.
According to our model, the Guardians (+1.5) have a 63% chance of covering the run line, while the over/under total of 7 runs has a 52% chance of going over.
Guardians vs. Astros Odds [7/7/2025]
We have sourced the best MLB odds in America for this game, which are listed here:
Bet Type | Guardians | Astros |
---|---|---|
Run Line | +1.5 (-190) | -1.5 (+160) |
Moneyline | +115 | -126 |
Total | o7 (-125) | u7 (+103) |
All odds are correct at the time of publication and are subject to change.
Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.
Guardians vs. Astros Picks and Best Bets
Our model's biggest edge in today's Guardians vs. Astros matchup is on the moneyline.
Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.
Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.
Calling Our Shot's Best Bets Today
Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.
Guardians vs. Astros Game-Day Updates and Essential Details
Monday's MLB action between the Astros and Guardians at Daikin Park is scheduled to start at 8:10PM ET.
- Who: Cleveland Guardians vs. Houston Astros
- Date: Monday, July 7, 2025
- Time: 8:10PM ET/5:10PM PT
- Venue: Daikin Park
Dimers.com's comprehensive preview of Monday's Guardians vs. Astros matchup includes our prediction, picks and the latest betting odds.
Before making any Guardians vs. Astros picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.
Conclusion
We predict the Astros, with a 55% win probability, will likely beat the Guardians on Monday.
AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Astros insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.
More on MLB
Keep up with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds offer the most accurate predictions for the World Series, American League, National League and each division.