Guardians vs. Tigers prediction: Detroit favored to win Wednesday's MLB matchup [9/17/2025]

The Detroit Tigers and Cleveland Guardians will lock horns in MLB action at Comerica Park on Wednesday, starting at 6:40PM ET.

Jack Flaherty (8-13, 4.69 ERA) will be the starting pitcher for the Tigers, while the Guardians will counter with Gavin Williams (10-5, 3.16 ERA).

Based on the latest simulations, Dimers' advanced MLB model projects the Tigers as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Guardians-Tigers game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Tigers' chance of winning at 58%, with the Guardians at 42%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Guardians vs. Tigers predictions page.

Tigers vs. Guardians prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the result of Wednesday's MLB game between the Guardians and Tigers 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Tigers a 58% chance of defeating the Guardians.

According to our model, the Guardians (+1.5) have a 61% chance of covering the run line, while the 8-run over/under has a 53% chance of going over.

Guardians vs. Tigers odds [9/17/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Guardians	Tigers
Run Line	+1.5 (-175)	-1.5 (+147)
Moneyline	+125	-136
Total	o8 (-110)	u8 (-109)

All odds are correct at the time of publication and are subject to change.

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Guardians vs. Tigers picks and best bets

Our model's strongest edge in today's Guardians vs. Tigers matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Guardians vs. Tigers game-day updates and essential details

Wednesday's MLB matchup between the Tigers and Guardians at Comerica Park is scheduled to start at 6:40PM ET.

• Who: Cleveland Guardians vs. Detroit Tigers
• Date: Wednesday, September 17, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: Comerica Park

Dimers' full preview of Wednesday's Guardians vs. Tigers matchup includes our prediction, picks and the latest betting odds.

Before making any Guardians vs. Tigers picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Tigers, with a 58% win probability, will likely beat the Guardians on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Tigers insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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