Guardians vs. Tigers prediction: Detroit favored to win Tuesday's MLB matchup [9/16/2025]

The Detroit Tigers and Cleveland Guardians are scheduled to meet in MLB action at Comerica Park on Tuesday, starting at 6:40PM ET.

Casey Mize (14-5, 3.83 ERA) will get the ball for the Tigers, pitting him against Joey Cantillo (5-3, 3.36 ERA) for the Guardians.

Based on updated simulations, Dimers' advanced MLB model predicts the Tigers as the most likely winner of today's game.

For further insights into Tuesday's matchup, including best bets and picks, visit our interactive Guardians vs. Tigers predictions page.

Tigers vs. Guardians prediction: Who will win, cover the run line?

Using innovative machine learning and statistical analysis, we have simulated the result of Tuesday's MLB matchup between the Guardians and Tigers 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Tigers a 56% chance of beating the Guardians.

According to our model, the Guardians (+1.5) have a 62% chance of covering the run line, while the over/under total of 8 runs has a 52% chance of going over.

Guardians vs. Tigers odds [9/16/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Guardians	Tigers
Run Line	+1.5 (-176)	-1.5 (+146)
Moneyline	+122	-142
Total	o8 (-110)	u8 (-105)

All odds are correct at the time of publication and are subject to change.

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Guardians vs. Tigers picks and best bets

Our model's strongest edge in today's Guardians vs. Tigers matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

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Guardians vs. Tigers game-day updates and essential details

Tuesday's MLB matchup between the Tigers and Guardians at Comerica Park is scheduled to commence at 6:40PM ET.

• Who: Cleveland Guardians vs. Detroit Tigers
• Date: Tuesday, September 16, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: Comerica Park

Dimers' full preview of Tuesday's Guardians vs. Tigers matchup includes our prediction, picks and the latest betting odds.

Before making any Guardians vs. Tigers picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Tigers, with a 56% win probability, will likely beat the Guardians on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Tigers insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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