Guardians vs. Tigers prediction: Cy Young candidate Tarik Skubal takes on Cleveland today [9/18/2025]

The Detroit Tigers will take on the Cleveland Guardians in MLB action at Comerica Park on Thursday, starting at 1:10PM ET.

Cy Young hopeful Tarik Skubal (13-5, 2.26 ERA) will get the ball for the Tigers, while the Guardians will counter with Tanner Bibee (10-11, 4.44 ERA).

Based on updated simulation results, Dimers' proven MLB model projects the Tigers as the most likely winner of today's game.

For further insights into Thursday's matchup, including best bets and picks, visit our interactive Guardians vs. Tigers predictions page.

Tigers vs. Guardians prediction: Who will win, cover the run line?

Using powerful machine learning and data, we have simulated the result of Thursday's MLB game between the Guardians and Tigers 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Tigers a 69% chance of defeating the Guardians.

According to our model, the Guardians (+1.5) have a 51% chance of covering the run line, while the over/under total of 7 runs has a 54% chance of going over.

Guardians vs. Tigers odds [9/18/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Guardians	Tigers
Run Line	+1.5 (-115)	-1.5 (-102)
Moneyline	+196	-225
Total	o7 (-109)	u7 (-110)

All odds are correct at the time of publication and are subject to change.

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Guardians vs. Tigers picks and best bets

Our model's strongest edge in today's Guardians vs. Tigers matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Guardians vs. Tigers game-day updates and essential details

Thursday's MLB matchup between the Tigers and Guardians at Comerica Park is scheduled to begin at 1:10PM ET.

• Who: Cleveland Guardians vs. Detroit Tigers
• Date: Thursday, September 18, 2025
• Time: 1:10PM ET/10:10AM PT
• Venue: Comerica Park

Dimers' comprehensive preview of Thursday's Guardians vs. Tigers matchup includes our prediction, picks and the latest betting odds.

Before making any Guardians vs. Tigers picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Tigers, with a 69% win probability, will likely beat the Guardians on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Tigers insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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