Guardians vs. Tigers Prediction: Detroit Predicted to Win Thursday's MLB Matchup [5/22/2025]

The Detroit Tigers will take on the Cleveland Guardians in MLB action at Comerica Park on Thursday, beginning at 6:40PM ET.

Jack Flaherty (2-5, 4.44 ERA) will start for the Tigers, while the Guardians will counter with Tanner Bibee (3-4, 4.06 ERA).

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Tigers as the most likely winner of today's game.

"Using the latest data, our experts simulated Thursday's Cleveland-Detroit game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Taking into account recent updates and various additional inputs, we forecast the Tigers with a win probability of 55% and the Guardians with 45%."

For further insights into Thursday's matchup, including best bets and picks, visit our interactive Guardians vs. Tigers predictions page.

Tigers vs. Guardians Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Thursday's MLB game between the Guardians and Tigers 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Tigers a 55% chance of beating the Guardians.

According to our model, the Guardians (+1.5) have a 64% chance of covering the run line, while the over/under total of 8 runs has a 52% chance of staying under.

Guardians vs. Tigers Odds [5/22/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Guardians	Tigers
Run Line	+1.5 (-198)	-1.5 (+170)
Moneyline	+110	-124
Total	o8 (-105)	u8 (-115)

All odds are correct at the time of publication and are subject to change.

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Guardians vs. Tigers Picks and Best Bets

Our model's biggest edge in today's Guardians vs. Tigers matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Guardians vs. Tigers Game-Day Updates and Essential Details

Thursday's MLB game between the Tigers and Guardians at Comerica Park is scheduled to commence at 6:40PM ET.

• Who: Cleveland Guardians vs. Detroit Tigers
• Date: Thursday, May 22, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: Comerica Park

Dimers.com's full preview of Thursday's Guardians vs. Tigers matchup includes our prediction, picks and the latest betting odds.

Before making any Cleveland vs. Detroit picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Tigers, with a 55% win probability, will likely beat the Guardians on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Tigers insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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