Guardians vs. Tigers Prediction: Detroit Predicted to Win Saturday's MLB Matchup [5/24/2025]

The Detroit Tigers will square off with the Cleveland Guardians in MLB action at Comerica Park on Saturday, starting at 7:15PM ET.

The Tigers will start Casey Mize (6-1, 2.53 ERA), while the Guardians have opted for Luis L. Ortiz (2-5, 4.66 ERA).

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Tigers as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's Cleveland-Detroit game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Tigers are more likely to win, while the Guardians have a lower chance of victory."

For expanded analysis of Saturday's matchup, including best bets and picks, visit our interactive Guardians vs. Tigers predictions page.

Tigers vs. Guardians Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the outcome of Saturday's MLB matchup between the Guardians and Tigers 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Tigers a 56% chance of beating the Guardians.

According to our model, the Guardians (+1.5) have a 62% chance of covering the run line, while the over/under total of 8 runs has a 55% chance of going over.

Guardians vs. Tigers Odds [5/24/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Guardians	Tigers
Run Line	+1.5 (-170)	-1.5 (+150)
Moneyline	+124	-142
Total	o8 (-110)	u8 (-108)

All odds are correct at the time of publication and are subject to change.

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Guardians vs. Tigers Picks and Best Bets

Our model's biggest edge in today's Guardians vs. Tigers matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Guardians vs. Tigers Game-Day Updates and Essential Details

Saturday's MLB game between the Tigers and Guardians at Comerica Park is scheduled to begin at 7:15PM ET.

• Who: Cleveland Guardians vs. Detroit Tigers
• Date: Saturday, May 24, 2025
• Time: 7:15PM ET/4:15PM PT
• Venue: Comerica Park

Dimers.com's in-depth preview of Saturday's Guardians vs. Tigers matchup includes our prediction, picks and the latest betting odds.

Before making any Cleveland vs. Detroit picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Tigers, with a 56% win probability, will likely beat the Guardians on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Tigers insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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