Guardians vs. Tigers Prediction: Detroit Predicted to Win Friday's MLB Matchup [5/23/2025]

The Detroit Tigers will take on the Cleveland Guardians, in what is expected to be a tight MLB game, at Comerica Park on Friday, beginning at 7:10PM ET.

Jackson Jobe (4-0, 4.12 ERA) will start on the mound for the Tigers, pitting him against Slade Cecconi (0-1, 5.40 ERA) for the Guardians.

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Tigers as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Cleveland-Detroit game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Tigers' chance of winning is 53%, while the Guardians' is 47%."

For further insights into Friday's matchup, including best bets and picks, visit our interactive Guardians vs. Tigers predictions page.

Tigers vs. Guardians Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data analysis, we have simulated the outcome of Friday's MLB game between the Guardians and Tigers 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Tigers a 53% chance of beating the Guardians.

According to our model, the Tigers (+1.5) have a 66% chance of covering the run line, while the over/under total of 8.5 runs has a 51% chance of going over.

Guardians vs. Tigers Odds [5/23/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Guardians	Tigers
Run Line	-1.5 (+165)	+1.5 (-192)
Moneyline	+102	-116
Total	o8.5 (-105)	u8.5 (-112)

All odds are correct at the time of publication and are subject to change.

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Guardians vs. Tigers Picks and Best Bets

Our model's biggest edge in today's Guardians vs. Tigers matchup is on the over/under.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Guardians vs. Tigers Game-Day Updates and Essential Details

Friday's MLB matchup between the Tigers and Guardians at Comerica Park is scheduled to start at 7:10PM ET.

• Who: Cleveland Guardians vs. Detroit Tigers
• Date: Friday, May 23, 2025
• Time: 7:10PM ET/4:10PM PT
• Venue: Comerica Park

Dimers.com's comprehensive preview of Friday's Guardians vs. Tigers matchup includes our prediction, picks and the latest betting odds.

Before making any Cleveland vs. Detroit picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

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Conclusion

We predict the Tigers, with a 53% win probability, will likely beat the Guardians on Friday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Tigers insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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