Guardians vs. Reds Prediction: Cleveland Predicted to Win Saturday's MLB Matchup [5/17/2025]

The Cincinnati Reds will take on the Cleveland Guardians, in what is expected to be a close MLB game, at Great American Ball Park on Saturday, starting at 6:40PM ET.

The Reds will start Brent Suter (1-0, 2.08 ERA), pitting him against Slade Cecconi (0-0, 0.00 ERA) for the Guardians.

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Guardians as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's Cleveland-Cincinnati game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Guardians are more likely to win, while the Reds have a lower chance of victory."

For further insights into Saturday's matchup, including best bets and picks, visit our interactive Guardians vs. Reds predictions page.

Reds vs. Guardians Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and statistical analysis, we have simulated the result of Saturday's MLB game between the Guardians and Reds 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Guardians a 51% chance of defeating the Reds.

According to our model, the Reds (+1.5) have a 60% chance of covering the run line, while the 10-run over/under has a 55% chance of staying under.

Guardians vs. Reds Odds [5/17/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Guardians	Reds
Run Line	-1.5 (+136)	+1.5 (-156)
Moneyline	-115	-102
Total	o10 (-104)	u10 (-115)

All odds are correct at the time of publication and are subject to change.

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Guardians vs. Reds Picks and Best Bets

Our model's biggest edge in today's Guardians vs. Reds matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Guardians vs. Reds Game-Day Updates and Essential Details

Saturday's MLB game between the Reds and Guardians at Great American Ball Park is scheduled to begin at 6:40PM ET.

• Who: Cleveland Guardians vs. Cincinnati Reds
• Date: Saturday, May 17, 2025
• Time: 6:40PM ET/3:40PM PT
• Venue: Great American Ball Park

Dimers.com's comprehensive preview of Saturday's Guardians vs. Reds matchup includes our prediction, picks and the latest betting odds.

Before making any Cleveland vs. Cincinnati picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Guardians, with a 51% win probability, will likely beat the Reds on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Reds insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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