Guardians vs. White Sox Prediction: Cleveland Predicted to Win Friday's MLB Matchup [8/8/2025]

MLB action continues on Friday at 7:40PM ET as the Cleveland Guardians square off with the Chicago White Sox at Rate Field.

Aaron Civale (3-6, 3.99 ERA) will be the starting pitcher for the White Sox, pitting him against Tanner Bibee (7-9, 4.51 ERA) for the Guardians.

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Guardians as the most likely winner of today's game.

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Guardians vs. White Sox predictions page.

White Sox vs. Guardians Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Friday's MLB matchup between the Guardians and White Sox 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Guardians a 54% chance of beating the White Sox.

According to our model, the White Sox (+1.5) have a 59% chance of covering the run line, while the over/under total of 8 runs has a 51% chance of staying under.

Guardians vs. White Sox Odds [8/8/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Guardians	White Sox
Run Line	-1.5 (+128)	+1.5 (-150)
Moneyline	-132	+115
Total	o8 (-115)	u8 (-104)

All odds are correct at the time of publication and are subject to change.

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Guardians vs. White Sox Picks and Best Bets

Our model's strongest edge in today's Guardians vs. White Sox matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Guardians vs. White Sox Game-Day Updates and Essential Details

Friday's MLB matchup between the White Sox and Guardians at Rate Field is scheduled to start at 7:40PM ET.

• Who: Cleveland Guardians vs. Chicago White Sox
• Date: Friday, August 8, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: Rate Field

Dimers.com's full preview of Friday's Guardians vs. White Sox matchup includes our prediction, picks and the latest betting odds.

Before making any Guardians vs. White Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Guardians, with a 54% win probability, will likely beat the White Sox on Friday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. White Sox insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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