Guardians vs. Cubs Prediction: Cubs Predicted to Win Wednesday's MLB Matchup [7/2/2025]

The Chicago Cubs and Cleveland Guardians are scheduled to meet in MLB action at Wrigley Field on Wednesday, starting at 8:05PM ET.

The Cubs will have Shota Imanaga (4-2, 2.54 ERA) as their starting pitcher, while the Guardians will counter with Tanner Bibee (4-8, 3.90 ERA).

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) projects the Cubs as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Guardians-Cubs game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Cubs' chance of winning at 63%, with the Guardians at 37%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Guardians vs. Cubs predictions page.

Cubs vs. Guardians Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and statistical analysis, we have simulated the result of Wednesday's MLB matchup between the Guardians and Cubs 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Cubs a 63% chance of beating the Guardians.

According to our model, the Guardians (+1.5) have a 60% chance of covering the run line, while the 8.5-run over/under has a 53% chance of staying under.

Guardians vs. Cubs Odds [7/2/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Guardians	Cubs
Run Line	+1.5 (-151)	-1.5 (+130)
Moneyline	+140	-162
Total	o8.5 (-102)	u8.5 (-119)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Guardians vs. Cubs Picks and Best Bets

Our model's biggest edge in today's Guardians vs. Cubs matchup is on the over/under.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Guardians vs. Cubs Game-Day Updates and Essential Details

Wednesday's MLB action between the Cubs and Guardians at Wrigley Field is scheduled to start at 8:05PM ET.

• Who: Cleveland Guardians vs. Chicago Cubs
• Date: Wednesday, July 2, 2025
• Time: 8:05PM ET/5:05PM PT
• Venue: Wrigley Field

Dimers.com's comprehensive preview of Wednesday's Guardians vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any Guardians vs. Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Conclusion

We predict the Cubs, with a 63% win probability, will likely beat the Guardians on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay up-to-date with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds provide the most accurate predictions for the World Series, American League, National League and each division.