Guardians vs. Red Sox prediction: Boston favored to win Wednesday's MLB matchup [9/3/2025]

MLB action continues on Wednesday at 6:45PM ET as the Cleveland Guardians take on the Boston Red Sox at Fenway Park.

The Red Sox will send Brennan Bernardino (4-2, 3.08 ERA) to the mound, up against Joey Cantillo (3-3, 3.94 ERA) for the Guardians.

Based on updated simulation results, Dimers' proven MLB model predicts the Red Sox as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Guardians-Red Sox game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Red Sox' chance of winning at 57%, with the Guardians at 43%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Guardians vs. Red Sox predictions page.

Red Sox vs. Guardians prediction: Who will win, cover the run line?

Using innovative machine learning and data analysis, we have simulated the result of Wednesday's MLB matchup between the Guardians and Red Sox 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Red Sox a 57% chance of defeating the Guardians.

According to our model, the Guardians (+1.5) have a 61% chance of covering the run line, while the over/under total of 8.5 runs has a 52% chance of going over.

Guardians vs. Red Sox odds [9/3/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Guardians	Red Sox
Run Line	+1.5 (-160)	-1.5 (+138)
Moneyline	+125	-142
Total	o8.5 (-115)	u8.5 (-101)

All odds are correct at the time of publication and are subject to change.

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Guardians vs. Red Sox picks and best bets

Our model's biggest edge in today's Guardians vs. Red Sox matchup is on the over/under.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Guardians vs. Red Sox game-day updates and essential details

Wednesday's MLB matchup between the Red Sox and Guardians at Fenway Park is scheduled to commence at 6:45PM ET.

• Who: Cleveland Guardians vs. Boston Red Sox
• Date: Wednesday, September 3, 2025
• Time: 6:45PM ET/3:45PM PT
• Venue: Fenway Park

Dimers.com's in-depth preview of Wednesday's Guardians vs. Red Sox matchup includes our prediction, picks and the latest betting odds.

Before making any Guardians vs. Red Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Red Sox, with a 57% win probability, will likely beat the Guardians on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Red Sox insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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