Guardians vs. Red Sox prediction: Boston favored to win Tuesday's MLB matchup [9/2/2025]

The Boston Red Sox will face the Cleveland Guardians in MLB action at Fenway Park on Tuesday, starting at 6:45PM ET.

The Red Sox will have Garrett Crochet (14-5, 2.40 ERA) as their starting pitcher, pitting him against Slade Cecconi (5-6, 4.41 ERA) for the Guardians.

Based on updated simulation results, Dimers' advanced MLB model projects the Red Sox as the most likely winner of today's game.

For expanded analysis of Tuesday's matchup, including best bets and picks, visit our interactive Guardians vs. Red Sox predictions page.

Red Sox vs. Guardians prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the result of Tuesday's MLB matchup between the Guardians and Red Sox 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Red Sox a 69% chance of defeating the Guardians.

According to our model, the Red Sox (-1.5) have a 51% chance of covering the run line, while the over/under total of 7.5 runs has a 53% chance of going over.

Guardians vs. Red Sox odds [9/2/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Guardians	Red Sox
Run Line	+1.5 (+105)	-1.5 (-118)
Moneyline	+220	-245
Total	o7.5 (-115)	u7.5 (-104)

All odds are correct at the time of publication and are subject to change.

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Guardians vs. Red Sox picks and best bets

Our model's biggest edge in today's Guardians vs. Red Sox matchup is on the over/under.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets video

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Guardians vs. Red Sox game-day updates and essential details

Tuesday's MLB action between the Red Sox and Guardians at Fenway Park is scheduled to commence at 6:45PM ET.

• Who: Cleveland Guardians vs. Boston Red Sox
• Date: Tuesday, September 2, 2025
• Time: 6:45PM ET/3:45PM PT
• Venue: Fenway Park

Dimers.com's in-depth preview of Tuesday's Guardians vs. Red Sox matchup includes our prediction, picks and the latest betting odds.

Before making any Guardians vs. Red Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Red Sox, with a 69% win probability, will likely beat the Guardians on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Red Sox insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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