Guardians vs. Red Sox prediction: Boston favored to win Labor Day MLB matchup [9/1/2025]

The Boston Red Sox and Cleveland Guardians will meet in MLB action at Fenway Park on Monday, starting at 1:35PM ET.

The Red Sox will have Brayan Bello (10-6, 2.99 ERA) as their starting pitcher, pitting him against Parker Messick (1-0, 0.66 ERA) for the Guardians.

Based on the latest simulation results, Dimers' advanced MLB model predicts the Red Sox as the most likely winner of today's game.

For further insights into Monday's matchup, including best bets and picks, visit our interactive Guardians vs. Red Sox predictions page.

Red Sox vs. Guardians prediction: Who will win, cover the run line?

Using powerful machine learning and statistical analysis, we have simulated the result of Monday's MLB game between the Guardians and Red Sox 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Red Sox a 57% chance of beating the Guardians.

According to our model, the Guardians (+1.5) have a 62% chance of covering the run line, while the 8-run over/under has a 53% chance of going over.

Guardians vs. Red Sox odds [9/1/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Guardians	Red Sox
Run Line	+1.5 (-164)	-1.5 (+150)
Moneyline	+125	-144
Total	o8 (-112)	u8 (-105)

All odds are correct at the time of publication and are subject to change.

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Guardians vs. Red Sox picks and best bets

Our model's biggest edge in today's Guardians vs. Red Sox matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free ⚾️ picks

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Guardians vs. Red Sox game-day updates and essential details

Monday's MLB action between the Red Sox and Guardians at Fenway Park is scheduled to commence at 1:35PM ET.

• Who: Cleveland Guardians vs. Boston Red Sox
• Date: Monday, September 1, 2025
• Time: 1:35PM ET/10:35AM PT
• Venue: Fenway Park

Dimers.com's full preview of Monday's Guardians vs. Red Sox matchup includes our prediction, picks and the latest betting odds.

Before making any Guardians vs. Red Sox picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Red Sox, with a 57% win probability, will likely beat the Guardians on Monday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Red Sox insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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