Guardians vs. Diamondbacks prediction: Arizona predicted to win Wednesday's MLB matchup [8/20/2025]

MLB action continues on Wednesday at 3:40PM ET as the Cleveland Guardians square off with the Arizona Diamondbacks at Chase Field.

The Diamondbacks will start Brandon Pfaadt (12-8, 5.08 ERA), while the Guardians have opted for Parker Messick (0-0, 0.00 ERA).

Based on the latest simulation results, Dimers' proven MLB model predicts the Diamondbacks as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Guardians-Diamondbacks game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Diamondbacks' chance of winning at 51%, with the Guardians at 49%."

For a closer look at Wednesday's matchup, including best bets and picks, visit our interactive Guardians vs. Diamondbacks predictions page.

Diamondbacks vs. Guardians prediction: Who will win?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Wednesday's MLB game between the Guardians and Diamondbacks 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Diamondbacks a 51% chance of defeating the Guardians.

According to our model, the over/under total of 9 runs also has an equal 50-50 chance of hitting.

Guardians vs. Diamondbacks odds [8/20/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Guardians	Diamondbacks
Moneyline	+100	-116
Total	o9 (-118)	u9 (+100)

All odds are correct at the time of publication and are subject to change.

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Guardians vs. Diamondbacks picks and best bets

Our model's strongest edge in today's Guardians vs. Diamondbacks matchup is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's best bets video

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Guardians vs. Diamondbacks game-day updates and essential details

Wednesday's MLB game between the Diamondbacks and Guardians at Chase Field is scheduled to start at 3:40PM ET.

• Who: Cleveland Guardians vs. Arizona Diamondbacks
• Date: Wednesday, August 20, 2025
• Time: 3:40PM ET/12:40PM PT
• Venue: Chase Field

Dimers.com's in-depth preview of Wednesday's Guardians vs. Diamondbacks matchup includes our prediction, picks and the latest betting odds.

Before making any Guardians vs. Diamondbacks picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Diamondbacks, with a 51% win probability, will likely beat the Guardians on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Diamondbacks insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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