Guardians vs. Diamondbacks prediction: Arizona predicted to win Tuesday's MLB matchup [8/19/2025]

MLB action continues on Tuesday at 9:40PM ET as the Cleveland Guardians lock horns with the Arizona Diamondbacks at Chase Field.

The Diamondbacks will start Eduardo Rodriguez (5-7, 5.40 ERA), up against Tanner Bibee (9-9, 4.54 ERA) for the Guardians.

Based on the latest simulation results, Dimers' advanced MLB model predicts the Diamondbacks as the most likely winner of today's game.

For a closer look at Tuesday's matchup, including best bets and picks, visit our interactive Guardians vs. Diamondbacks predictions page.

Diamondbacks vs. Guardians prediction: Who will win, cover the run line?

Using trusted machine learning and data analysis, we have simulated the result of Tuesday's MLB matchup between the Guardians and Diamondbacks 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Diamondbacks a 53% chance of defeating the Guardians.

According to our model, the Guardians (+1.5) have a 65% chance of covering the run line, while the over/under total of 8.5 runs has a 53% chance of going over.

Guardians vs. Diamondbacks odds [8/19/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Guardians	Diamondbacks
Run Line	+1.5 (-220)	-1.5 (+165)
Moneyline	+105	-118
Total	o8.5 (-118)	u8.5 (+100)

All odds are correct at the time of publication and are subject to change.

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Guardians vs. Diamondbacks picks and best bets

Our model's biggest edge in today's Guardians vs. Diamondbacks matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

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Guardians vs. Diamondbacks game-day updates and essential details

Tuesday's MLB matchup between the Diamondbacks and Guardians at Chase Field is scheduled to start at 9:40PM ET.

• Who: Cleveland Guardians vs. Arizona Diamondbacks
• Date: Tuesday, August 19, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: Chase Field

Dimers.com's in-depth preview of Tuesday's Guardians vs. Diamondbacks matchup includes our prediction, picks and the latest betting odds.

Before making any Guardians vs. Diamondbacks picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Diamondbacks, with a 53% win probability, will likely beat the Guardians on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Diamondbacks insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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