Guardians vs. Diamondbacks prediction: Arizona predicted to win Monday's MLB matchup [8/18/2025]

The Arizona Diamondbacks will take on the Cleveland Guardians in MLB action at Chase Field on Monday, starting at 9:40PM ET.

Zac Gallen (9-12, 5.31 ERA) will start for the Diamondbacks, while the Guardians are going with Gavin Williams (7-4, 3.38 ERA).

Based on the latest simulations, Dimers' advanced MLB model projects the Diamondbacks as the most likely winner of today's game.

For further insights into Monday's matchup, including best bets and picks, visit our interactive Guardians vs. Diamondbacks predictions page.

Diamondbacks vs. Guardians prediction: Who will win?

Using innovative machine learning and data, we have simulated the result of Monday's MLB matchup between the Guardians and Diamondbacks 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Diamondbacks a 53% chance of defeating the Guardians.

According to our model, the 9-run over/under has a 52% chance of staying under.

Guardians vs. Diamondbacks odds [8/18/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Guardians	Diamondbacks
Moneyline	+105	-120
Total	o9 (-105)	u9 (-114)

All odds are correct at the time of publication and are subject to change.

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Guardians vs. Diamondbacks picks and best bets

Our model's strongest edge in today's Guardians vs. Diamondbacks matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Guardians vs. Diamondbacks game-day updates and essential details

Monday's MLB game between the Diamondbacks and Guardians at Chase Field is scheduled to commence at 9:40PM ET.

• Who: Cleveland Guardians vs. Arizona Diamondbacks
• Date: Monday, August 18, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: Chase Field

Dimers.com's comprehensive preview of Monday's Guardians vs. Diamondbacks matchup includes our prediction, picks and the latest betting odds.

Before making any Guardians vs. Diamondbacks picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Diamondbacks, with a 53% win probability, will likely beat the Guardians on Monday.

AI and automation have enhanced this article to quickly deliver accurate Guardians vs. Diamondbacks insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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