Cavaliers vs. Spurs Prediction: Cleveland to Win, Donovan Mitchell Projected for 26 Points in Friday's NBA Game [4/4/2025]

The San Antonio Spurs will face the favored Cleveland Cavaliers in NBA action at Frost Bank Center on Friday, starting at 8:00PM ET.

Based on updated simulation results and today’s injury updates, Dimers' advanced NBA model (see Dimers Pro for full access) predicts the Cavaliers as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Cleveland-San Antonio game 10,000 times," said Damien Souness from Dimers.

"After computing the latest updates and thousands of other inputs, we predict the Cavaliers' chance of winning is 83%, while the Spurs' is 17%."

This prediction follows the latest NBA Injury Report, which suggests the Spurs lineup will feature stars like Stephon Castle, Devin Vassell and Keldon Johnson, while the Cavaliers will be led by Donovan Mitchell, Evan Mobley and Darius Garland.

For a closer look at Friday's matchup, including an expanded look at the predicted score, best bets and player prop picks, visit our interactive Cavaliers vs. Spurs predictions page.

EXCLUSIVE OFFER: Sign up to Dimers Pro with code MARCH today to enjoy a full month for the price of just one week!

Cavaliers vs. Cavaliers Prediction: Who Will Win, Cover the Spread?

Using powerful machine learning and data, we have simulated the result of Friday's NBA matchup between the Cavaliers and Spurs 10,000 times as part of our NBA predictions coverage.

Our independent predictive model gives the Cavaliers an 83% chance of beating the Spurs. Our predicted final score has the Cavaliers winning 125-114.

According to our model, the Spurs (+12.5) have a 56% chance of covering the spread, while the 241.5-point over/under has a 54% chance of staying under.

Cavaliers vs. Spurs Odds

We have researched the best NBA odds in America for this game, which are listed here:

Bet Type	Cavaliers	Spurs
Spread	-12.5 (-110)	+12.5 (-110)
Moneyline	-700	+525
Total	o241.5 (-108)	u241.5 (-110)

All odds are correct at the time of publication and are subject to change.

Boost your NBA betting by exploring the latest NBA betting promos, sourced from top sportsbooks and DFS operators.

Cavaliers vs. Spurs Picks and Best Bets

Our model's strongest edge in today's Cavaliers vs. Spurs matchup is on the total.

Our expert predictions, aligned with the latest odds, reveal the best NBA picks and NBA best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Cavaliers vs. Spurs Player Props

Betting on Cleveland vs. San Antonio NBA prop bets? We use the best information available to project how each team's leading players will perform at Frost Bank Center.

Donovan Mitchell is expected to lead the Cavaliers with 26 points, 5 rebounds and 7 assists, while Stephon Castle is projected to have 19 points, 4 rebounds and 5 assists for the Spurs.

Dimers Pro users can access a full range of player props and projected box scores, including points, assists, rebounds and more, for every NBA game this season.

Cavs vs. Spurs Game-Day Updates and Essential Details

Friday's matchup between the Spurs and Cavaliers at Frost Bank Center is scheduled to commence at 8:00PM ET.

• Who: Cleveland Cavaliers vs. San Antonio Spurs
• Date: Friday, April 4, 2025
• Time: 8:00PM ET/5:00PM PT
• Venue: Frost Bank Center

Dimers.com's full preview of Friday's Cavaliers vs. Spurs matchup includes our prediction, picks and the latest betting odds.

Before making any Cleveland vs. San Antonio picks, be sure to check out the latest NBA predictions and betting advice from Dimers Pro.

Sports Betting Deals Available for Friday

To make the most of Friday's mammoth day of sports, headlined by a massive night of NBA, MLB and NHL action, check out details on the latest Bet365 bonus code "DIMERS" that scores you the choice of two excellent signup promotions. Don't miss out!

Conclusion

We predict the Cavaliers, with an 83% win probability, will likely beat the Spurs on Friday.

AI and automation have enhanced this article to quickly deliver accurate Cavaliers vs. Spurs insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on NBA

Keep up with the latest NBA news and NBA parlay picks throughout the season. Plus, our NBA championship odds offer the most up-to-date predictions for the NBA title.