Browns vs. Lions prediction: Detroit favored to win in NFL Week 4, 2025

NFL Week 4 action continues on Sunday at 1:00PM ET as the Cleveland Browns take on the favored Detroit Lions at Ford Field.

Based on updated simulations, Dimers' proven NFL model predicts the Lions as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Browns-Lions game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Lions with a win probability of 80%, while the Browns have 20%."

This gameday Browns vs. Lions betting preview builds on my Browns vs. Lions prediction that was posted earlier in the week.

For expanded analysis of today’s game, including the predicted score, best bets and player prop picks, visit our interactive Browns vs. Lions predictions page.

Browns vs. Lions Predictions

Since our Browns-Lions predictions earlier in the week, we have simulated the outcome of Sunday's NFL matchup between the Browns and Lions 10,000 times as part of our NFL predictions coverage.

Our famous predictive model gives the Lions an 80% chance of beating the Browns in Week 4 of the NFL season. Our predicted final score has the Lions winning 26-17.

According to our model, the Browns (+9.5) have a 53% chance of covering the spread, while the 44.5-point over/under has an equal 50-50 chance of hitting.

Browns vs. Lions odds

We have sourced the best NFL odds in America for this game, which are listed here:

Bet Type	Browns	Lions
Spread	+9.5 (+100)	-9.5 (-122)
Moneyline	+450	-550
Total	o44.5 (-105)	u44.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Browns vs. Lions picks and best bets

Our model's strongest edge in today's Browns vs. Lions matchup is on the over/under.

Our expert predictions, aligned with the current odds, reveal the best NFL picks and NFL best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Browns vs. Lions TD scorers

Who will score the first touchdown in Browns vs. Lions?

According to our model, Detroit's Jahmyr Gibbs is most likely to score the first TD in Browns vs. Lions.

Our projections give Gibbs a 15.5% chance of scoring the first TD at Ford Field, while the Lions running back is a 59.9% chance of reaching the end zone at any point during the game.

First touchdown scorer predictions

Cleveland Browns

Player	First TD Probability
Quinshon Judkins (RB)	9.4%
Jerry Jeudy (WR)	4.9%
Cedric Tillman (WR)	4.7%

Detroit Lions

Player	First TD Probability
Jahmyr Gibbs (RB)	15.5%
David Montgomery (RB)	11.5%
Amon-Ra St. Brown (WR)	9.7%

Anytime touchdown scorer predictions

Cleveland Browns

Player	Anytime TD Probability
Quinshon Judkins (RB)	41.4%
Jerry Jeudy (WR)	24.5%
Cedric Tillman (WR)	23.6%

Detroit Lions

Player	Anytime TD Probability
Jahmyr Gibbs (RB)	59.9%
David Montgomery (RB)	49.2%
Amon-Ra St. Brown (WR)	43.5%

Browns vs Lions player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Browns and Lions. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our Browns-Lions page now to access every player prop projection.

Browns vs. Lions quarterbacks

Of the starting quarterbacks, the Browns' Joe Flacco is projected to throw for more yards than the Lions' Jared Goff.

Browns rushing

Quinshon Judkins, Jerome Ford and Dylan Sampson are projected to be the leading rushers for the Browns.

Player	Position
Quinshon Judkins	RB
Jerome Ford	RB
Dylan Sampson	RB

Lions rushing

Jahmyr Gibbs, David Montgomery and Jameson Williams are expected to lead the Lions in rushing yards.

Player	Position
Jahmyr Gibbs	RB
David Montgomery	RB
Jameson Williams	WR

Browns receiving

Jerry Jeudy, Cedric Tillman, David Njoku, Harold Fannin and Jerome Ford are projected to top the receiving yards for the Browns.

Player	Position
Jerry Jeudy	WR
Cedric Tillman	WR
David Njoku	TE
Harold Fannin	TE
Jerome Ford	RB

Lions receiving

Amon-Ra St. Brown, Jameson Williams, Sam LaPorta, Jahmyr Gibbs and Isaac TeSlaa are projected to lead the Lions in receiving yards.

Player	Position
Amon-Ra St. Brown	WR
Jameson Williams	WR
Sam LaPorta	TE
Jahmyr Gibbs	RB
Isaac TeSlaa	WR

Browns vs. Lions game-day updates and essential details

The NFL Week 4 game between the Lions and Browns at Ford Field is scheduled to begin at 1:00PM ET.

• Who: Cleveland Browns vs. Detroit Lions
• Date: Sunday, September 28, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Ford Field

Dimers' in-depth preview of this week's Browns vs. Lions matchup includes our prediction, picks and the latest betting odds.

Before making any Browns vs. Lions picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Lions, with an 80% win probability, will likely beat the Browns in Week 4 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Browns vs. Lions insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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