Cleveland Browns vs. Detroit Lions early prediction: Expert picks for NFL Week 4, 2025

The Cleveland Browns and Detroit Lions will meet in Week 4 of the NFL season at Ford Field on Sunday, September 28, 2025, starting at 1:00PM ET.

Initial simulations from Dimers' trusted NFL model favor the Lions as the most likely winner of this matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Browns vs. Lions predictions page.

Cleveland vs. Detroit early predictions

Leveraging trusted machine learning and analysis, we have simulated the Browns vs. Lions game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Browns 17%, Lions 83%
• Predicted final score: Browns 17-27 Lions
• Spread: Browns (+10.5) 50%, Lions (-10.5) 50%
• Total points (45.5): Over 50%, Under 50%

As of September 21, 2025, these Browns-Lions calculations and predictions reflect the latest data and insights available.

Browns vs. Lions Week 4 details

The NFL Week 4 matchup between the Lions and Browns at Ford Field is scheduled for September 28, 2025.

• Who: Cleveland Browns vs. Detroit Lions
• Date: Sunday, September 28, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Ford Field

Browns vs. Lions opening odds

We've researched the best betting odds across America for this Week 4 game, which are listed here:

• Spread: Browns +10.5 (-112), Lions -10.5 (-108)
• Moneyline: Browns +400, Lions -535
• Total: Over/Under 45.5 (-110/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Lions, with an 83% win probability, will likely beat the Browns in Week 4 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Browns vs. Lions matchup, with human oversight maintaining high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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