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Reds vs. Nationals Prediction: Cincinnati Predicted to Win Monday's MLB Matchup [7/21/2025]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Our expert prediction for Monday's Cincinnati Reds vs Washington Nationals matchup.
MLB action continues on Monday at 6:45PM ET as the Cincinnati Reds lock horns with the Washington Nationals at Nationals Park.
The Nationals will start Jake Irvin (7-5, 4.58 ERA), while the Reds have opted for Brady Singer (7-7, 4.32 ERA).
Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Reds as the most likely winner of today's game.
For further insights into Monday's matchup, including best bets and picks, visit our interactive Reds vs. Nationals predictions page.
Nationals vs. Reds Prediction: Who Will Win, Cover the Run Line?
Using trusted machine learning and data, we have simulated the outcome of Monday's MLB matchup between the Reds and Nationals 10,000 times as part of our MLB predictions coverage.
Our leading predictive model currently gives the Reds a 51% chance of defeating the Nationals.
According to our model, the Nationals (+1.5) have a 61% chance of covering the run line, while the 9-run over/under has a 51% chance of staying under.
Reds vs. Nationals Odds [7/21/2025]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Reds | Nationals |
|---|---|---|
| Run Line | -1.5 (+130) | +1.5 (-146) |
| Moneyline | -122 | +105 |
| Total | o9 (-118) | u9 (-102) |
All odds are correct at the time of publication and are subject to change.
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Reds vs. Nationals Picks and Best Bets
Our model's biggest edge in today's Reds vs. Nationals matchup is on the over/under.
Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.
Unlimited access to our full set of picks, including this one, is available via Dimers Pro.
Calling Our Shot's Best Bets
Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.
Reds vs. Nationals Game-Day Updates and Essential Details
Monday's MLB game between the Nationals and Reds at Nationals Park is scheduled to begin at 6:45PM ET.
- Who: Cincinnati Reds vs. Washington Nationals
- Date: Monday, July 21, 2025
- Time: 6:45PM ET/3:45PM PT
- Venue: Nationals Park
Dimers.com's comprehensive preview of Monday's Reds vs. Nationals matchup includes our prediction, picks and the latest betting odds.
Before making any Reds vs. Nationals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.
Conclusion
We predict the Reds, with a 51% win probability, will likely beat the Nationals on Monday.
AI and automation have enhanced this article to quickly deliver accurate Reds vs. Nationals insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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