Reds vs. Cardinals prediction: Tight battle projected in updated analysis for Wednesday's MLB matchup [9/17/2025]

The St. Louis Cardinals will take on the Cincinnati Reds, in what is expected to be a tight MLB game, at Busch Stadium on Wednesday, beginning at 1:15PM ET.

Andre Pallante (6-14, 5.23 ERA) will be on the bump for the Cardinals, up against Brady Singer (13-10, 3.94 ERA) for the Reds.

Based on the latest simulations, Dimers' advanced MLB model predicts an equal chance for both the Cardinals and Reds to win today's game.

"Our team has simulated the outcome of Wednesday's Reds-Cardinals game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Based on the latest updates and extensive data, we predict a 50-50 chance for both the Cardinals and Reds, making it a highly competitive matchup."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Reds vs. Cardinals predictions page.

Cardinals vs. Reds prediction: Who will win, cover the run line?

Using innovative machine learning and data, we have simulated the result of Wednesday's MLB game between the Reds and Cardinals 10,000 times as part of our MLB predictions coverage.

Our famous predictive model can't split the two teams, giving both the Reds and Cardinals a 50% chance of winning the game.

According to our model, the Cardinals (+1.5) have a 63% chance of covering the run line, while the 8.5-run over/under has a 52% chance of going over.

Reds vs. Cardinals odds [9/17/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Reds	Cardinals
Run Line	-1.5 (+145)	+1.5 (-165)
Moneyline	-120	+103
Total	o8.5 (-104)	u8.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Reds vs. Cardinals picks and best bets

Our model's strongest edge in today's Reds vs. Cardinals matchup is on the total.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

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Reds vs. Cardinals game-day updates and essential details

Wednesday's MLB game between the Cardinals and Reds at Busch Stadium is scheduled to begin at 1:15PM ET.

• Who: Cincinnati Reds vs. St. Louis Cardinals
• Date: Wednesday, September 17, 2025
• Time: 1:15PM ET/10:15AM PT
• Venue: Busch Stadium

Dimers' full preview of Wednesday's Reds vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Reds vs. Cardinals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict a close game between the Reds and Cardinals on Wednesday, with each team having a 50% chance of winning.

AI and automation have enhanced this article to quickly deliver accurate Reds vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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