Reds vs. Cardinals prediction: Cincinnati favored to win Tuesday's MLB matchup [9/16/2025]

MLB action continues on Tuesday at 7:45PM ET as the Cincinnati Reds square off with the St. Louis Cardinals at Busch Stadium.

Michael McGreevy (6-3, 4.44 ERA) will be the starting pitcher for the Cardinals, while the Reds have opted for Andrew Abbott (9-6, 2.79 ERA).

Based on updated simulations, Dimers' proven MLB model projects the Reds as the most likely winner of today's game.

For further insights into Tuesday's matchup, including best bets and picks, visit our interactive Reds vs. Cardinals predictions page.

Cardinals vs. Reds prediction: Who will win, cover the run line?

Using innovative machine learning and data, we have simulated the outcome of Tuesday's MLB game between the Reds and Cardinals 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Reds a 52% chance of defeating the Cardinals.

According to our model, the Cardinals (+1.5) have a 61% chance of covering the run line, while the 8-run over/under has a 52% chance of going over.

Reds vs. Cardinals odds [9/16/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Reds	Cardinals
Run Line	-1.5 (+140)	+1.5 (-160)
Moneyline	-123	+106
Total	o8 (-105)	u8 (-113)

All odds are correct at the time of publication and are subject to change.

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Reds vs. Cardinals picks and best bets

Our model's strongest edge in today's Reds vs. Cardinals matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

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Reds vs. Cardinals game-day updates and essential details

Tuesday's MLB game between the Cardinals and Reds at Busch Stadium is scheduled to begin at 7:45PM ET.

• Who: Cincinnati Reds vs. St. Louis Cardinals
• Date: Tuesday, September 16, 2025
• Time: 7:45PM ET/4:45PM PT
• Venue: Busch Stadium

Dimers' full preview of Tuesday's Reds vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Reds vs. Cardinals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Reds, with a 52% win probability, will likely beat the Cardinals on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Reds vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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