Reds vs. Cardinals prediction: St. Louis favored to win Monday's MLB matchup [9/15/2025]

MLB action continues on Monday at 7:45PM ET as the Cincinnati Reds lock horns with the St. Louis Cardinals at Busch Stadium.

Matthew Liberatore (7-12, 4.35 ERA) will start for the Cardinals, pitting him against Zack Littell (9-8, 3.78 ERA) for the Reds.

Based on updated simulations, Dimers' advanced MLB model projects the Cardinals as the most likely winner of today's game.

For further insights into Monday's matchup, including best bets and picks, visit our interactive Reds vs. Cardinals predictions page.

Cardinals vs. Reds prediction: Who will win?

Using powerful machine learning and data, we have simulated the result of Monday's MLB matchup between the Reds and Cardinals 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Cardinals a 53% chance of defeating the Reds.

According to our model, the 8.5-run over/under has a 53% chance of going over.

Reds vs. Cardinals odds [9/15/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Reds	Cardinals
Moneyline	-105	-110
Total	o8.5 (-110)	u8.5 (-102)

All odds are correct at the time of publication and are subject to change.

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Reds vs. Cardinals picks and best bets

Our model's biggest edge in today's Reds vs. Cardinals matchup is on the moneyline.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Reds vs. Cardinals game-day updates and essential details

Monday's MLB matchup between the Cardinals and Reds at Busch Stadium is scheduled to start at 7:45PM ET.

• Who: Cincinnati Reds vs. St. Louis Cardinals
• Date: Monday, September 15, 2025
• Time: 7:45PM ET/4:45PM PT
• Venue: Busch Stadium

Dimers' comprehensive preview of Monday's Reds vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

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Conclusion

We predict the Cardinals, with a 53% win probability, will likely beat the Reds on Monday.

AI and automation have enhanced this article to quickly deliver accurate Reds vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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