Reds vs. Cardinals Prediction: Cincinnati Predicted to Win Sunday's MLB Matchup [6/22/2025]

MLB action continues on Sunday at 2:15PM ET as the Cincinnati Reds square off with the St. Louis Cardinals at Busch Stadium.

The Cardinals will send Miles Mikolas (4-4, 4.36 ERA) to the mound, while the Reds will counter with Andrew Abbott (6-1, 1.84 ERA).

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Reds as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Reds-Cardinals game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Reds with a win probability of 51%, while the Cardinals have 49%."

For a closer look at Sunday's matchup, including best bets and picks, visit our interactive Reds vs. Cardinals predictions page.

Cardinals vs. Reds Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Sunday's MLB game between the Reds and Cardinals 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Reds a 51% chance of defeating the Cardinals.

According to our model, the Cardinals (+1.5) have a 62% chance of covering the run line, while the over/under total of 9 runs has a 53% chance of staying under.

Reds vs. Cardinals Odds [6/22/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Reds	Cardinals
Run Line	-1.5 (+140)	+1.5 (-164)
Moneyline	-112	-104
Total	o9 (-130)	u9 (+100)

All odds are correct at the time of publication and are subject to change.

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Reds vs. Cardinals Picks and Best Bets

Our model's strongest edge in today's Reds vs. Cardinals matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Reds vs. Cardinals Game-Day Updates and Essential Details

Sunday's MLB game between the Cardinals and Reds at Busch Stadium is scheduled to start at 2:15PM ET.

• Who: Cincinnati Reds vs. St. Louis Cardinals
• Date: Sunday, June 22, 2025
• Time: 2:15PM ET/11:15AM PT
• Venue: Busch Stadium

Dimers.com's full preview of Sunday's Reds vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Reds vs. Cardinals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
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Conclusion

We predict the Reds, with a 51% win probability, will likely beat the Cardinals on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Reds vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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