Reds vs. Cardinals Prediction: St. Louis Predicted to Win Saturday's MLB Matchup [6/21/2025]

MLB action continues on Saturday at 2:15PM ET as the Cincinnati Reds take on the St. Louis Cardinals at Busch Stadium.

The Cardinals will have Sonny Gray (7-2, 3.84 ERA) as their starting pitcher, while the Reds will counter with Brent Suter (1-0, 2.91 ERA).

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Cardinals as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's Reds-Cardinals game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Cardinals are more likely to win, while the Reds have a lower chance of victory."

For expanded analysis of Saturday's matchup, including best bets and picks, visit our interactive Reds vs. Cardinals predictions page.

Cardinals vs. Reds Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data analysis, we have simulated the outcome of Saturday's MLB game between the Reds and Cardinals 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Cardinals a 64% chance of beating the Reds.

According to our model, the Reds (+1.5) have a 54% chance of covering the run line, while the 9-run over/under has a 53% chance of staying under.

Reds vs. Cardinals Odds [6/21/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Reds	Cardinals
Run Line	+1.5 (-119)	-1.5 (+105)
Moneyline	+168	-198
Total	o9 (-110)	u9 (-105)

All odds are correct at the time of publication and are subject to change.

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Reds vs. Cardinals Picks and Best Bets

Our model's biggest edge in today's Reds vs. Cardinals matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free ⚾️ Picks

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Reds vs. Cardinals Game-Day Updates and Essential Details

Saturday's MLB game between the Cardinals and Reds at Busch Stadium is scheduled to commence at 2:15PM ET.

• Who: Cincinnati Reds vs. St. Louis Cardinals
• Date: Saturday, June 21, 2025
• Time: 2:15PM ET/11:15AM PT
• Venue: Busch Stadium

Dimers.com's full preview of Saturday's Reds vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Reds vs. Cardinals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cardinals, with a 64% win probability, will likely beat the Reds on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Reds vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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