Reds vs. Cardinals Prediction: St. Louis Predicted to Win Friday's MLB Matchup [6/20/2025]

The St. Louis Cardinals and Cincinnati Reds will lock horns in MLB action at Busch Stadium on Friday, starting at 7:15PM ET.

Andre Pallante (4-3, 4.83 ERA) will start for the Cardinals, while the Reds have opted for Brady Singer (7-4, 4.34 ERA).

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) projects the Cardinals as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Reds-Cardinals game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Cardinals' chance of winning is 56%, while the Reds' is 44%."

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Reds vs. Cardinals predictions page.

Cardinals vs. Reds Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Friday's MLB matchup between the Reds and Cardinals 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Cardinals a 56% chance of beating the Reds.

According to our model, the Reds (+1.5) have a 62% chance of covering the run line, while the over/under total of 8.5 runs has a 52% chance of staying under.

Reds vs. Cardinals Odds [6/20/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Reds	Cardinals
Run Line	+1.5 (-176)	-1.5 (+150)
Moneyline	+120	-140
Total	o8.5 (-122)	u8.5 (+100)

All odds are correct at the time of publication and are subject to change.

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Reds vs. Cardinals Picks and Best Bets

Our model's strongest edge in today's Reds vs. Cardinals matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Free MLB Picks

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Reds vs. Cardinals Game-Day Updates and Essential Details

Friday's MLB action between the Cardinals and Reds at Busch Stadium is scheduled to start at 7:15PM ET.

• Who: Cincinnati Reds vs. St. Louis Cardinals
• Date: Friday, June 20, 2025
• Time: 7:15PM ET/4:15PM PT
• Venue: Busch Stadium

Dimers.com's comprehensive preview of Friday's Reds vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Reds vs. Cardinals picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cardinals, with a 56% win probability, will likely beat the Reds on Friday.

AI and automation have enhanced this article to quickly deliver accurate Reds vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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