Reds vs. Padres prediction: San Diego favored to win Wednesday's MLB matchup [9/10/2025]

The San Diego Padres will square off with the Cincinnati Reds in MLB action at PETCO Park on Wednesday, commencing at 8:40PM ET.

The Padres will start Nick Pivetta (13-5, 2.85 ERA), while the Reds have opted for Andrew Abbott (8-6, 2.88 ERA).

Based on the latest simulation results, Dimers' advanced MLB model predicts the Padres as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Reds-Padres game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Padres' chance of winning at 59%, with the Reds at 41%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Reds vs. Padres predictions page.

Padres vs. Reds prediction: Who will win, cover the run line?

Using innovative machine learning and statistical analysis, we have simulated the result of Wednesday's MLB game between the Reds and Padres 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Padres a 59% chance of defeating the Reds.

According to our model, the Reds (+1.5) have a 60% chance of covering the run line, while the over/under total of 7.5 runs has a 51% chance of going over.

Reds vs. Padres odds [9/10/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Reds	Padres
Run Line	+1.5 (-181)	-1.5 (+155)
Moneyline	+127	-144
Total	o7.5 (-105)	u7.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Reds vs. Padres picks and best bets

Our model's biggest edge in today's Reds vs. Padres matchup is on the total.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

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Reds vs. Padres game-day updates and essential details

Wednesday's MLB action between the Padres and Reds at PETCO Park is scheduled to start at 8:40PM ET.

• Who: Cincinnati Reds vs. San Diego Padres
• Date: Wednesday, September 10, 2025
• Time: 8:40PM ET/5:40PM PT
• Venue: PETCO Park

Dimers' in-depth preview of Wednesday's Reds vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Reds vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Padres, with a 59% win probability, will likely beat the Reds on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Reds vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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