Reds vs. Padres prediction: San Diego favored to win Monday's MLB matchup [9/8/2025]

The San Diego Padres and Cincinnati Reds will meet in MLB action at PETCO Park on Monday, starting at 9:40PM ET.

Yu Darvish (3-5, 5.75 ERA) will get the ball for the Padres, up against Nick Lodolo (8-7, 3.22 ERA) for the Reds.

Based on updated simulations, Dimers' advanced MLB model predicts the Padres as the most likely winner of today's game.

For expanded analysis of Monday's matchup, including best bets and picks, visit our interactive Reds vs. Padres predictions page.

Padres vs. Reds prediction: Who will win, cover the run line?

Using trusted machine learning and data, we have simulated the outcome of Monday's MLB game between the Reds and Padres 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Padres a 56% chance of defeating the Reds.

According to our model, the Reds (+1.5) have a 63% chance of covering the run line, while the 7.5-run over/under has an equal 50-50 chance of hitting.

Reds vs. Padres odds [9/8/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Reds	Padres
Run Line	+1.5 (-184)	-1.5 (+156)
Moneyline	+120	-138
Total	o7.5 (+100)	u7.5 (-109)

All odds are correct at the time of publication and are subject to change.

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Reds vs. Padres picks and best bets

Our model's biggest edge in today's Reds vs. Padres matchup is on the run line.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's free MLB picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Reds vs. Padres game-day updates and essential details

Monday's MLB matchup between the Padres and Reds at PETCO Park is scheduled to commence at 9:40PM ET.

• Who: Cincinnati Reds vs. San Diego Padres
• Date: Monday, September 8, 2025
• Time: 9:40PM ET/6:40PM PT
• Venue: PETCO Park

Dimers' comprehensive preview of Monday's Reds vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Reds vs. Padres picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Padres, with a 56% win probability, will likely beat the Reds on Monday.

AI and automation have enhanced this article to quickly deliver accurate Reds vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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